1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Tavapadon

Tavapadon (Synonyms: PF-06649751; CVL-751)

Cat. No.: HY-119486
Handling Instructions

Tavapadon (PF-06649751; CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease.

For research use only. We do not sell to patients.

Tavapadon Chemical Structure

Tavapadon Chemical Structure

CAS No. : 1643489-24-0

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Description

Tavapadon (PF-06649751; CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease[1].

IC50 & Target

dopamine D1/D5 receptor[1]

In Vivo

Tavapadon (PF-06649751; CVL-751; 0.02 and 0.04 mg/kg; s.c.) at the 0.04 mg/kg test dose increases locomotor activity, whereas the 0.02 mg/kg dose has little or no effect[1].
Tavapadon (0.04 mg/kg, s.c.) also improves parkinsonian disability scores with the maximal improvement observed at 110 min after drug administration[1].
Higher doses of Tavapadon (0.1 and 0.15 mg/kg; s.c.) leads to statistically significant improvement relative to vehicle in locomotor activity[1].
Tavapadon (0.1 mg/kg; s.c.) has the mean maximal unbound plasma concentration of 8 nM and achieves 3 hours after compound administration in captive-bred macaques[1].

Molecular Weight

391.34

Formula

C₁₉H₁₆F₃N₃O₃

CAS No.

1643489-24-0

SMILES

O=C1NC(C(C)=C(C2=CC=C(OC3=NC=CC=C3C(F)(F)F)C=C2C)N1C)=O.[(-)].[Rotation]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TavapadonPF-06649751CVL-751PF06649751PF 06649751CVL751CVL 751Dopamine ReceptororallydopamineD1/D5receptorenablingmovementreducingdisabilityParkinson'sdiseaseInhibitorinhibitorinhibit

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