1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Tavapadon

Tavapadon  (Synonyms: PF-06649751; CVL-751)

Cat. No.: HY-119486 Purity: 99.22%
COA Handling Instructions

Tavapadon (PF-06649751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease.

For research use only. We do not sell to patients.

Tavapadon Chemical Structure

Tavapadon Chemical Structure

CAS No. : 1643489-24-0

Size Price Stock Quantity
5 mg USD 220 In-stock
10 mg USD 350 In-stock
25 mg USD 640 In-stock
50 mg USD 895 In-stock
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200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tavapadon:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tavapadon

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tavapadon (PF-06649751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease[1].

IC50 & Target

dopamine D1/D5 receptor[1]

In Vivo

Tavapadon (PF-06649751; 0.02 and 0.04 mg/kg; s.c.) at the 0.04 mg/kg test dose increases locomotor activity, whereas the 0.02 mg/kg dose has little or no effect[1].
Tavapadon (0.04 mg/kg, s.c.) also improves parkinsonian disability scores with the maximal improvement observed at 110 min after drug administration[1].
Higher doses of Tavapadon (0.1 and 0.15 mg/kg; s.c.) leads to statistically significant improvement relative to vehicle in locomotor activity[1].
Tavapadon (0.1 mg/kg; s.c.) has the mean maximal unbound plasma concentration of 8 nM and achieves 3 hours after compound administration in captive-bred macaques[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

391.34

Formula

C19H16F3N3O3

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1NC(C(C)=C(C2=CC=C(OC3=NC=CC=C3C(F)(F)F)C=C2C)N1C)=O.[(-)].[Rotation]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (255.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5553 mL 12.7766 mL 25.5532 mL
5 mM 0.5111 mL 2.5553 mL 5.1106 mL
10 mM 0.2555 mL 1.2777 mL 2.5553 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 2.5 mg/mL (6.39 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Tavapadon Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Tavapadon
Cat. No.:
HY-119486
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