1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. PW0464

PW0464 

Cat. No.: HY-141495
Handling Instructions

PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP).

For research use only. We do not sell to patients.

PW0464 Chemical Structure

PW0464 Chemical Structure

CAS No. : 1643462-93-4

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Description

PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP)[1].

In Vitro

PW0464 (compound 24) is found to elicit complete G protein bias, showing no activity for D1R-mediated β-arrestin recruitment[1].
PW0464 (compound 24), the non-catechol agonist, forms bonds with S1985.42 and S2025.46 via its fluorine atom[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

389.35

Formula

C₁₉H₁₇F₂N₃O₄

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PW0464
Cat. No.:
HY-141495
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