Epoxide Hydrolase

Related Products

Epoxide hydrolases (EH) present in all living organisms. The mammalian soluble epoxide hydrolase (sEH) is a 120 kDa dimer of two identical 62.5 kDa monomers arranged in an anti-parallel fashion. It is mostly expressed in the liver, kidneys, brain, endothelium, and at lesser levels in other tissues. Inflammation and pain are major components of many disease states. Mammalian sEH inhibition reduces blood pressure, inflammation and pain. The anti-inflammatory activities of sEH inhibitors occur in part through the NF-κB mediated down-regulation of COX2 transcription, resulting in lower production of pro-inflammatory prostaglandins such as PGE2 and PGD2.

Epoxide Hydrolase Related Products (90)
Antibodies (1)

By Effects:	Inhibitors (78) Degraders (3) Ligand (1) Activator (1) Modulator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W013989

1,3-Dicyclohexylurea	Inhibitor	99.85%
1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats.

HY-W027340

ARM1	Inhibitor	99.60%
ARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC₅₀ 7.61 µM and epoxide hydrolase inhibitory activity with an IC₅₀ 12.4 µM.

HY-148136

sEH inhibitor-7	Inhibitor	99.50%
sEH inhibitor-7 is an sEH inhibitor, with an IC₅₀ of 0.15 μM against mouse sEH and an IC₅₀ of 6.2 μM against h-sEH. sEH inhibitor-7 can be used in studies related to hypertension and inflammation.

HY-W097200

1,3-Dibenzylurea	Inhibitor	99.92%
1,3-Dibenzylurea is an insect growth regulator and a mouse soluble epoxide hydrolase (MsEH) inhibitor.

HY-W013989R

1,3-Dicyclohexylurea (Standard)	Inhibitor
1,3-Dicyclohexylurea (Standard) is the analytical standard of 1,3-Dicyclohexylurea. This product is intended for research and analytical applications. 1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats.

HY-121538A

CUDA disodium	Inhibitor	98.0%
CUDA disodium is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC₅₀s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA disodium selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA disodium may be valuable for the research of cardiovascular disease.

HY-120494

sEH inhibitor-1	Inhibitor	99.62%
sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC₅₀s of 0.4 and 5.3 nM in human and murine, respectively.

HY-135653A

(Rac)-EC5026	Inhibitor	98.25%
(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) extracted from patent WO2019156991A1, page 39, has a K_i of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB).

HY-147049

PAL-4	Activator	99.10%
PAL-4 (compound 4) is a potent, selective and reversible Lysophospholipase-like 1 (LYPLAL1) activator with EC₅₀ value of 0.39 μM and 0.49 μM for mice LYPLAL1 and huamn LYPLAL1, respectively. PAL-4 can be used for researching metabolic disorders.

HY-121549

S-NEPC		98%
S-NEPC (4-Nitrophenyl-2S,3S-epoxy-3 phenylpropyl carbonate) is a colorimetric substrate used to measure epoxide hydrolase activity.

HY-135795

1-Cyclohexyl-3-dodecyl urea	Inhibitor	98.0%
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.

HY-W104814

sEH/FXR-IN-1	Ligand	≥98.0%
sEH/FXR-IN-1 (compound 9) is a soluble epoxide hydrolase (sEH) and FXR ligand.

HY-170492

sEH inhibitor-19	Inhibitor
sEH inhibitor-19 (Compound (R)-14i) is an orally active inhibitor for soluble epoxide hydrolase (sEH) with an IC₅₀ of 1.2 nM. sEH inhibitor-19 inhibits the expression of TNF-α and IL-6, exhibits anti-inflammatory activity in mouse acute pancreatitis or Carrageenan (HY-125474)-induced edema models.

HY-168144

DJ-53	Inhibitor
DJ-53 (compund 68) is an orally active phenylquinoline-based soluble epoxide hydrolase inhibitor.

HY-159121

sEH inhibitor-17	Inhibitor
sEH inhibitor-17 (compound 4f) is an oral active soluble epoxide hydrolase (sEH) inhibitor with the IC₅₀ of 2.94 nM. sEH inhibitor-17 shows anti-inflammatory efficacy.

HY-148000

sEH inhibitor-6	Inhibitor
sEH inhibitor-6 (Compound 3g) is a soluble epoxide hydrolase (sEH) inhibitor with an IC₅₀ of 0.5 nM.

HY-175392

PROTAC sEH-degrader-3	Degrader
PROTAC sEH-degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that can selectively degrade sEH in the cytosol without affecting sEH in peroxisomes. PROTAC sEH-degrader-3 degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasome, with an IC₅₀ of 0.8 nM against hsEH. PROTAC sEH-degrader-3 can inhibit endoplasmic reticulum stress and can be used in the research of inflammation, metabolic diseases, and other diseases related to endoplasmic reticulum stress.

HY-155029

sEH inhibitor-16	Inhibitor
sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC₅₀ of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research.

HY-N15524

Thalictoside	Inhibitor
Thalictoside is found in A. squamosa L. Thalictoside is a sEH inhibitor (IC₅₀: 20.2 µM). Thalictoside exerts anti-osteoporotic effects through an estrogen-like mechanism. Thalictoside can be used in the research of cardiovascular and urinary diseases.

HY-W587945

(E)-3-Feruloylquinic acid	Inhibitor
(E)-3-Feruloylquinic acid (Compound 3) is a chlorogenic acid. (E)-3-Feruloylquinic acid can be isolated from the aerial parts of Tetrastigma hemsleyanum. (E)-3-Feruloylquinic acid inhibits soluble epoxide hydrolase (sEH) with an IC₅₀ of 60.7 μM. (E)-3-Feruloylquinic acid can be used in the study of vascular system diseases.

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Epoxide Hydrolase

Epoxide Hydrolase

Epoxide Hydrolase Related Products (90)

Antibodies (1)

Epoxide Hydrolase Related Products (90):