PROTAC sEH degrader-3
PROTAC sEH degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that can selectively degrade sEH in the cytosol without affecting sEH in peroxisomes. PROTAC sEH degrader-3 degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasome, with an IC50 of 0.8 nM against hsEH. PROTAC sEH degrader-3 can inhibit endoplasmic reticulum stress and can be used in the research of inflammation, metabolic diseases, and other diseases related to endoplasmic reticulum stress.
(Pink: sEH ligand (HY-114266); Blue: Cereblon ligand (HY-14658); Black: linker (HY-W008352)).
For research use only. We do not sell to patients.
- CAS No.: 3093413-94-3
- Formula: C46H53F3N6O14
- Molecular Weight:970.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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Cereblon |
Chemical Information
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CAS No. 3093413-94-3
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Molecular Weight 970.94
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Formula C46H53F3N6O14
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SMILES
O=C(COC1=C(C2=O)C(C(N2C3CCC(NC3=O)=O)=O)=CC=C1)NCCOCCOCCOCCOCCNC(C4=CC=C(O[C@@H]5CC[C@H](CC5)NC(NC6=CC=C(OC(F)(F)F)C=C6)=O)C=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC sEH degrader-3 Related Classifications
HY-175392 Related Classifications
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