3093413-94-3
Chemical Structure
PROTAC sEH degrader-3
- CAS No.: 3093413-94-3
- Formula:C46H53F3N6O14
- Molecular Weight:970.94
IUPAC Name: N-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)-4-(((1r,4r)-4-(3-(4-(trifluoromethoxy)phenyl)ureido)cyclohexyl)oxy)benzamide
InChIKey: STGMSTZSBJPAMZ-YRLQYNNYSA-N
SMILES: O=C(COC1=C(C2=O)C(C(N2C3CCC(NC3=O)=O)=O)=CC=C1)NCCOCCOCCOCCOCCNC(C4=CC=C(O[C@@H]5CC[C@H](CC5)NC(NC6=CC=C(OC(F)(F)F)C=C6)=O)C=C4)=O
Biological Activity: PROTAC sEH degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that can selectively degrade sEH in the cytosol without affecting sEH in peroxisomes. PROTAC sEH degrader-3 degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasome, with an IC50 of 0.8 nM against hsEH. PROTAC sEH degrader-3 can inhibit endoplasmic reticulum stress and can be used in the research of inflammation, metabolic diseases, and other diseases related to endoplasmic reticulum stress[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PROTAC sEH degrader-3 | PROTAC sEH degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that can selectively degrade sEH in the cytosol without affecting sEH in peroxisomes. PROTAC sEH degrader-3 degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasome, with an IC50 of 0.8 nM against hsEH. PROTAC sEH degrader-3 can inhibit endoplasmic reticulum stress and can be used in the research of inflammation, metabolic diseases, and other diseases related to endoplasmic reticulum stress. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
