sEH inhibitor-1
Based on 1 Customer Validation
sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 1208549-68-1
- Formula: C17H20F3N3O3
- Molecular Weight:371.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
sEH[1]
| Doses (mg/kg) | Cmaxa (nmol/L) | Tmax (h)a | AUCt (uM h)a | MRT (h)a |
| 0.1 (0.27d) | 270±120 | 5.3±1.2 | 2.2±1.1 | 18.9±6.6 |
| 0.3 (0.81d) | 1680±1170 | 4.7±1.2 | 16.6±8.8 | 16.9±5.4 |
| 1.0 (2.69d) | 2560±95 | 3.2±2.2 | 43.8±5.1 | 24.0±1.8 |
| 3.0 (8.08d) | 5160±265 | 3.9±2.5 | 94.3±8.0 | 32.1±5.6 |
d: The dose with the unit of μmol/kg.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1208549-68-1
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Appearance Solid
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Molecular Weight 371.35
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Formula C17H20F3N3O3
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Color White to off-white
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SMILES
O=C(NC1=CC=C(C=C1)OC(F)(F)F)NC2CCN(CC2)C(C3CC3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (336.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6929 mL | 13.4644 mL | 26.9288 mL | 67.3219 mL |
| 5 mM | 0.5386 mL | 2.6929 mL | 5.3858 mL | 13.4644 mL | |
| 10 mM | 0.2693 mL | 1.3464 mL | 2.6929 mL | 6.7322 mL | |
| 15 mM | 0.1795 mL | 0.8976 mL | 1.7953 mL | 4.4881 mL | |
| 20 mM | 0.1346 mL | 0.6732 mL | 1.3464 mL | 3.3661 mL | |
| 25 mM | 0.1077 mL | 0.5386 mL | 1.0772 mL | 2.6929 mL | |
| 30 mM | 0.0898 mL | 0.4488 mL | 0.8976 mL | 2.2441 mL | |
| 40 mM | 0.0673 mL | 0.3366 mL | 0.6732 mL | 1.6830 mL | |
| 50 mM | 0.0539 mL | 0.2693 mL | 0.5386 mL | 1.3464 mL | |
| 60 mM | 0.0449 mL | 0.2244 mL | 0.4488 mL | 1.1220 mL | |
| 80 mM | 0.0337 mL | 0.1683 mL | 0.3366 mL | 0.8415 mL | |
| 100 mM | 0.0269 mL | 0.1346 mL | 0.2693 mL | 0.6732 mL |
sEH inhibitor-1 Related Classifications
HY-120494 Related Classifications
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