1. Metabolic Enzyme/Protease
  2. Epoxide Hydrolase
  3. sEH inhibitor-1

sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively.

For research use only. We do not sell to patients.

sEH inhibitor-1 Chemical Structure

sEH inhibitor-1 Chemical Structure

CAS No. : 1208549-68-1

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1 mg USD 60 In-stock
5 mg USD 200 In-stock
10 mg USD 320 In-stock
25 mg USD 640 In-stock
50 mg USD 1050 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].

IC50 & Target

sEH[1]

In Vivo

Pharmacokinetic parameters of sEH inhibitor-1 (TCPU) after oral gavage with a non-compartmental analysis[1].

Doses (mg/kg) Cmaxa (nmol/L) Tmax (h)a AUCt (uM•h)a MRT (h)a
0.1 (0.27d) 270±120 5.3±1.2 2.2±1.1 18.9±6.6
0.3 (0.81d) 1680±1170 4.7±1.2 16.6±8.8 16.9±5.4
1.0 (2.69d) 2560±95 3.2±2.2 43.8±5.1 24.0±1.8
3.0 (8.08d) 5160±265 3.9±2.5 94.3±8.0 32.1±5.6
a: Tmax, the time of maximum concentration; Cmax, the maximum blood concentration; MRT, the mean residence time; and AUCt, area under the concentration–time curve to terminal time. Additional PK parameters with non-compartmental model are presented in Table S3.
d: The dose with the unit of μmol/kg.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

371.35

Formula

C17H20F3N3O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(C=C1)OC(F)(F)F)NC2CCN(CC2)C(C3CC3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (336.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6929 mL 13.4644 mL 26.9288 mL
5 mM 0.5386 mL 2.6929 mL 5.3858 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6929 mL 13.4644 mL 26.9288 mL 67.3219 mL
5 mM 0.5386 mL 2.6929 mL 5.3858 mL 13.4644 mL
10 mM 0.2693 mL 1.3464 mL 2.6929 mL 6.7322 mL
15 mM 0.1795 mL 0.8976 mL 1.7953 mL 4.4881 mL
20 mM 0.1346 mL 0.6732 mL 1.3464 mL 3.3661 mL
25 mM 0.1077 mL 0.5386 mL 1.0772 mL 2.6929 mL
30 mM 0.0898 mL 0.4488 mL 0.8976 mL 2.2441 mL
40 mM 0.0673 mL 0.3366 mL 0.6732 mL 1.6830 mL
50 mM 0.0539 mL 0.2693 mL 0.5386 mL 1.3464 mL
60 mM 0.0449 mL 0.2244 mL 0.4488 mL 1.1220 mL
80 mM 0.0337 mL 0.1683 mL 0.3366 mL 0.8415 mL
100 mM 0.0269 mL 0.1346 mL 0.2693 mL 0.6732 mL
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sEH inhibitor-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
sEH inhibitor-1
Cat. No.:
HY-120494
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