1. Metabolic Enzyme/Protease
  2. Epoxide Hydrolase
  3. sEH inhibitor-1

sEH inhibitor-1 

Cat. No.: HY-120494
Handling Instructions

sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively.

For research use only. We do not sell to patients.

sEH inhibitor-1 Chemical Structure

sEH inhibitor-1 Chemical Structure

CAS No. : 1208549-68-1

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sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively[1].

IC50 & Target


In Vivo

Pharmacokinetic parameters of sEH inhibitor-1 (TCPU) after oral gavage with a non-compartmental analysis[1].

Doses (mg/kg) Cmaxa (nmol/L) Tmax (h)a AUCt (uM•h)a MRT (h)a
0.1 (0.27d) 270±120 5.3±1.2 2.2±1.1 18.9±6.6
0.3 (0.81d) 1680±1170 4.7±1.2 16.6±8.8 16.9±5.4
1.0 (2.69d) 2560±95 3.2±2.2 43.8±5.1 24.0±1.8
3.0 (8.08d) 5160±265 3.9±2.5 94.3±8.0 32.1±5.6
a: Tmax, the time of maximum concentration; Cmax, the maximum blood concentration; MRT, the mean residence time; and AUCt, area under the concentration–time curve to terminal time. Additional PK parameters with non-compartmental model are presented in Table S3.
d: The dose with the unit of μmol/kg.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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