Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10876):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0228S9

Adenosine-¹³C₁₀,¹⁵N₅		99.60%
Adenosine-¹³C₁₀,¹⁵N₅ is the ¹³C and ¹⁵N labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-N1150S11

Thymidine-¹³C₁₀
Thymidine-¹³C₁₀ (DThyd-¹³C₁₀; NSC 21548-¹³C₁₀) is ¹³C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-133668S

Monoethyl phthalate-d₄		98.36%
Monoethyl phthalate-d₄ is the deuterium labeled Monoethyl phthalate. Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms.

HY-W010542S

Azepan-2-one-d₁₀		99.8%
Azepan-2-one-d₁₀ is the deuterium labeled Azepan-2-one.

HY-150707S

DL-A-phosphatidylcholine, dipalmitoyl-¹³C₄₀
DL-A-phosphatidylcholine, dipalmitoyl-¹³C₄₀ is the ¹³C labeled DL-A-phosphatidylcholine, dipalmitoyl.

HY-W067358S

2-Methylpyrazine-d₆		98.81%
2-Methylpyrazine-d₆ is the deuterium labeled 2-Methylpyrazine. 2-Methylpyrazine is a kind of alkylpyrazine that can be identified in roasted red pepper seed oils.

HY-10585S4

Valproic acid-d₄-1		99.5%
Valproic acid-d₄-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.

HY-13757S

Tamoxifen-d₃ hydrochloride		98.99%
Tamoxifen-d₃ hydrochloride is deuterated labeled Tamoxifen (Citrate) (HY-13757). Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis.Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse.

HY-100573S

Necrosulfonamide-d₄		99.65%
Necrosulfonamide-d₄ is the deuterium labeled Necrosulfonamide (HY-100573). Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.

HY-45842S

4,6-Dichloro-N-methylpyridazine-3-carboxamide-d₃		98.51%
4,6-Dichloro-N-methylpyridazine-3-carboxamide-d₃ is the deuterium labeled 4,6-Dichloro-N-methylpyridazine-3-carboxamide (HY-45842).

HY-50935S

Troglitazone-d₄		98.19%
Troglitazone-d₄ is deuterium labeled Troglitazone. Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively.

HY-Y0978S

Boc-Glycine-¹⁵N		98.0%
Boc-Glycine-¹⁵N is the ¹⁵N labeled Boc-Glycine.

HY-W023144S

Tris(1-chloro-2-propyl) phosphate-d₁₈
Tris(1-chloro-2-propyl) phosphate-d₁₈ (Tris(1-chloropropan-2-yl) phosphate-d₁₈) is a deuterium labeled compound.

HY-B0234S4

Estrone-d₂-1		99.75%
Estrone-d₂-1 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells.

HY-18569S1

3-Indoleacetic acid-d₄		99.40%
3-Indoleacetic acid-d₄ (Indole-3-acetic acid-d₄; 3-IAA-d₄) is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

HY-N0470S4

L-Lysine-d₈ hydrochloride		99.88%
L-Lysine-d₈ (hydrochloride) is the deuterium labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-N0680S1

Thiamine-d₃ hydrochloride		98.92%
Thiamine-d₃ (hydrochloride) is the deuterium labeled Thiamine hydrochloride. Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.

HY-N0390S10

L-Glutamine-1,2-¹³C₂		98.0%
L-Glutamine-1,2-¹³C₂ is the ¹³C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.

HY-Y0366S2

Lauric acid-d₂		99.80%
Lauric acid-d₂ is the deuterium labeled Lauric acid. Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

HY-78004S

1,2-Diphenylethane-d₁₄		99.5%
1,2-Diphenylethane-d₁₄ is the deuterium labeled 1,2-Diphenylethane.

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