SHP2
Src homology phosphatase 2; PTPN11
Src-homology-2-containing protein tyrosine phosphatase 2 (SHP2), encoded by the PTPN11 gene, is a 593 amino acid classical non-receptor protein tyrosine phosphatase (PTP). SHP2 is involved in diverse signalling pathways such as RAS-MAPK, PI3K-AKT, JAK-STAT and PD-1/PD-L1. Besides, SHP2 negatively regulates the activation of recombinant NLRP3 (NLR family, pyrin domain containing protein 3) inflammasome via mitochondrial homeostasis. SHP2 has been regarded as an extremely attractive target for human diseases therapies, particular in cancer.
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SHP2 Related Products (107)
Related Products (107)
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Antibodies (1)
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SHP2-IN-19
0 ImagesCat. No.: HY-155275CAS No.: 2941498-84-4SHP2-IN-19 (compound 183) is a SHP2 inhibitor with an IC50 value of 3 nM. SHP2-IN-19 can be used for glioblastoma research.
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SHP844
0 ImagesCat. No.: HY-125260CAS No.: 2222280-82-0SHP844 is a SHP2 inhibitor with the IC50 of 18.9 µM. SHP2 is a protein tyrosine phosphatase (PTP) that regulates tyrosine phosphorylation levels and is involved in cell proliferation, differentiation and survival.
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SHP2-IN-40
0 ImagesCat. No.: HY-171960CAS No.: 2056002-39-0
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Suchilactone
0 ImagesCat. No.: HY-N10079CAS No.: 50816-74-5Synonyms: Jatrophan
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SHP2-IN-21
0 ImagesCat. No.: HY-155277CAS No.: 2941499-08-5SHP2-IN-21 (compound 208) is a SHP2 inhibitor with an IC50 value of 3 nM. SHP2-IN-21 can be used for glioblastoma research.
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SHP2-IN-47
0 ImagesCat. No.: HY-181800SHP2-IN-47 is a selective and potent SHP2 inhibitor with an IC50 of 0.80 μM. SHP2-IN-47 exhibits potent inhibitory activity against SHP2E76K (IC50 = 0.37 μM). SHP2-IN-47 functionally inhibits protein tyrosine phosphatase domains and downregulates SHP2-mediated phosphorylation of AKT and ERK. SHP2-IN-47 induces apoptosis and suppresses proliferation of cancer cells. SHP2-IN-47 can be used for the research of cancer, such as acute myelocytic leukemia.
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SDUY104
0 ImagesCat. No.: HY-184412SDUY104 is an orally active amide-based allosteric inhibitor of SHP2 with an IC50 of 140 nM. SDUY104 impairs KRAS-driven pancreatic cancer cell proliferation via cell-cycle arrest and apoptosis. SDUY104 suppresses MAPK signaling and triggers compensatory PI3K-AKT activation. SDUY104 can be used for KRAS-mutant pancreatic cancer research.
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SHP2-IN-18
0 ImagesCat. No.: HY-155274CAS No.: 2941498-87-7SHP2-IN-18 (compound 183) is a SHP2 inhibitor with an IC50 value of 3 nM. SHP2-IN-18 can be used for glioblastoma research.
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TK-642
0 ImagesCat. No.: HY-158762CAS No.: 2765183-10-4
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CD31 TFA
0 ImagesCat. No.: HY-P3444ASynonyms: PECAM-1 TFACD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation-.
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SDUY038
0 ImagesCat. No.: HY-159489CAS No.: 2892720-11-3
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SHP2/NAMPT-IN-1
0 ImagesCat. No.: HY-184650SHP2/NAMPT-IN-1 is an orally active dual inhibitor of SHP2 and NAMPT, with IC50 values of 30.5 nM and 24.4 nM, respectively. SHP2/NAMPT-IN-1 reduces NAD+ levels and p-ERK expression by inhibiting NAMPT. SHP2/NAMPT-IN-1 can inhibit the migration and colony formation of MDA-MB-231 cells and promote apoptosis. SHP2/NAMPT-IN-1 has anti-proliferative activity against a variety of tumor cell lines and can reverse PD-L1-mediated T-cell immunosuppression. SHP2/NAMPT-IN-1 can be used for breast cancer research.
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RMC-3943
0 ImagesCat. No.: HY-141524CAS No.: 1801764-60-2
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SHP504
0 ImagesCat. No.: HY-125259CAS No.: 2222280-83-1
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SHP2-IN-34
0 ImagesCat. No.: HY-169918CAS No.: 2924065-12-1SHP2-IN-34 (compound A8) is a phenyl urea SHP2 inhibitor with anti-cancer activity. SHP2-IN-34 significantly suppresses tumor growth in CT26 mouse model.
