CD31 TFA
CD31 (PECAM-1) TFA is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 TFA is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation. CD31 TFA peptide is able to sustain phosphorylation of the CD31 ITIM686 and of SHP2 and to inhibit TCR-induced T-cell activation-.
For research use only. We do not sell to patients.
- Formula: C121H203F3N36O31
- Molecular Weight:2715.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CD31 TFA is a trans-homophilic co-signaling protein at the crossroad between mechanical stress, metabolism and inflammation[1].
CD31 TFA is a ER-MP12 antigen, exerts function as promoting cell adhesion between endothelial cells, enabling transmigration of leukocytes across vascular endothelium, and producing signaling to up-regulation of other adhesion molecules in neighboring cells[2].
Clostridium perfringens b-toxin (CPB) is a highly active b-pore-forming toxin (b-PFT) and the essential virulence factor for fatal, necro-hemorrhagic enteritis[3].
CD31 TFA serves as the specific membrane receptor for clostridium perfringens b-toxin (CPB) on endothelial cells. CD31 TFA directly interacts with CPB, with the membrane proximal Ig6 domain[3].
CD31 TFA also serves as a therapeutic target in atherosclerosis[4].
CD31 TFA (0, 25, 50, 100 μg/mL) induces proliferative response to TCR engagement of human PBMCs in a dose-dependent manner[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 2715.12
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Formula C121H203F3N36O31
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Synonyms
PECAM-1 TFA
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Sequence Shortening
NHASSVPRSKILTVRVILAPWKK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Caligiuri G. Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology. Cardiovasc Res. 2019 Jul 1. 115(9):1425-1434. [Content Brief]
[2]. Ling V, et al. Structural identification of the hematopoietic progenitor antigen ER-MP12 as the vascular endothelial adhesion molecule PECAM-1 (CD31). Eur J Immunol. 1997 Feb. 27(2):509-14. [Content Brief]
[3]. Bruggisser J, et al. CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. Cell Host Microbe. 2020 Jul 8. 28(1):69-78.e6. [Content Brief]
[4]. Caligiuri G. CD31 as a Therapeutic Target in Atherosclerosis. Circ Res. 2020 Apr 24. 126(9):1178-1189. [Content Brief]
[5]. Fornasa G, et al. TCR stimulation drives cleavage and shedding of the ITIM receptor CD31. J Immunol. 2010 May 15. 184(10):5485-92. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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