SHP2-IN-38
SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC50 values of 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), 33.07 μM (TCPTP). SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4-11 cells proliferation in vitro with IC50 of 7.90 μM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish.
For research use only. We do not sell to patients.
- Formula: C20H15N3O3S
- Molecular Weight:377.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SHP2-IN-38 (0-20 μM, 3days) shows a strong ability to inhibit cell proliferation of MV4-11 with an IC50 value of 7.90 μM[1].
SHP2-IN-38 (20 μM, 24 h) reduces the phosphorylation level of p-ERK in MV4-11 cells[1].
SHP2-IN-38 (10-100 μM) exhibits two distinct absorption peaks at 320 nm and 360 nm, with 360 nm selected as the optimal excitation wavelength, and a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF[1].
SHP2-IN-38 (20 μM, 16 h) has good fluorescence imaging in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 377.42
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Formula C20H15N3O3S
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SMILES
OC1=C(C(O)=O)C=C(C2=CN(N=C(/C=C/C3=CC=C(C)C=C3)S4)C4=N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SHP2-IN-38 Related Classifications
HY-174322 Related Classifications
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