1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. RMC-3943

RMC-3943 

Cat. No.: HY-141524
Handling Instructions

RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM).

For research use only. We do not sell to patients.

RMC-3943 Chemical Structure

RMC-3943 Chemical Structure

CAS No. : 1801764-60-2

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Description

RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM)[1].

In Vitro

RMC-3943 inhibits pERK in PC9 cells, with an IC50 of 35.5 nM[1].
RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: SK-MEL-113 cells[1].
Concentration: 0-10 μM.
Incubation Time: 7 days.
Result: Inhibited cell proliferation.
Molecular Weight

425.38

Formula

C₁₈H₂₂Cl₂N₆S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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RMC-3943
Cat. No.:
HY-141524
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