RMC-3943
RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM).
For research use only. We do not sell to patients.
- CAS No.: 1801764-60-2
- Formula: C18H22Cl2N6S
- Molecular Weight:425.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
RMC-3943 inhibits pERK in PC9 cells, with an IC50 of 35.5 nM[1].
RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-MEL-113 cells[1].
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Concentration:0-10 μM.
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Incubation Time:7 days.
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Result:Inhibited cell proliferation.
Chemical Information
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CAS No. 1801764-60-2
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Molecular Weight 425.38
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Formula C18H22Cl2N6S
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SMILES
N[C@H]1C2(CCC1)CCN(C3=NC(N)=C(N=C3)SC4=CC=NC(Cl)=C4Cl)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RMC-3943 Related Classifications
HY-141524 Related Classifications
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