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Cat. No.: HY-176796

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SHP2-IN-43

SHP2-IN-43 (Compound 5) is a SHP2 inhibitor with an IC₅₀ of 98.7 nM. SHP2-IN-43 can be used as a PROTAC target ligand in the synthesis of SHP2-D26 (HY-145162).

For research use only. We do not sell to patients.

CAS No.: 2458219-45-7
Formula: C₁₈H₂₃ClN₆OS
Molecular Weight:406.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

SHP2-IN-43 Chemical Structure

CAS No.: 2458219-45-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

SHP2-IN-43 (Compound 5) is a SHP2 inhibitor with an IC₅₀ of 98.7 nM. SHP2-IN-43 can be used as a PROTAC target ligand in the synthesis of SHP2-D26 (HY-145162)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	6.6 μM Compound: 5	Growth inhibition of human MV4-11 cells measured after 4 days by WST8 assay Growth inhibition of human MV4-11 cells measured after 4 days by WST8 assay	[PMID: 32437146]

Chemical Information

CAS No. 2458219-45-7
Molecular Weight 406.93
Formula C₁₈H₂₃ClN₆OS
SMILES

ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang M, et al. Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein. J Med Chem. 2020 Jul 23;63(14):7510-7528. doi: 10.1021/acs.jmedchem.0c00471. Epub 2020 May 21. Erratum in: J Med Chem. 2021 Jan 14;64(1):906-908. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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