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Art. -Nr.: HY-159489

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SDUY038

SDUY038 is a SHP2 allosteric inhibitor, with an IC₅₀ of 1.2 μM and K_D of 0.29 μM, respectively. SDUY038 exhibits pan-antitumor activity (IC₅₀ = 7-24 μM) by suppressing pERK expression. SDUY038 exhibits t_1/2 of 3.95 h by oral administration.

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CAS. Nr.: 2892720-11-3
Formel: C₁₇H₁₈Cl₂N₂O₂S
Molecular Weight:385.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SDUY038 Chemical Structure

CAS. Nr.: 2892720-11-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	7.3 μM Compound: 21; SDUY038	Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 39066713]
5637	IC₅₀	23.3 μM Compound: 21; SDUY038	Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 39066713]
HCT-116	IC₅₀	15.5 μM Compound: 21; SDUY038	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 39066713]
HepG2	IC₅₀	11.4 μM Compound: 21; SDUY038	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 39066713]
MDA-MB-468	IC₅₀	12.8 μM Compound: 21; SDUY038	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 39066713]
RT-4	IC₅₀	12.5 μM Compound: 21; SDUY038	Antiproliferative activity against human RT-4 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against human RT-4 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 39066713]
RT-4	IC₅₀	5.1 μM Compound: 21; SDUY038	Antitumor activity against human RT-4 cells cultured as organoids assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Antitumor activity against human RT-4 cells cultured as organoids assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 39066713]
SW1990	IC₅₀	11 μM Compound: 21; SDUY038	Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 39066713]
SW480	IC₅₀	9.9 μM Compound: 21; SDUY038	Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 39066713]
T-24	IC₅₀	23.9 μM Compound: 21; SDUY038	Antiproliferative activity against human T24 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay Antiproliferative activity against human T24 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay	[PMID: 39066713]

Chemical Information

CAS. Nr. 2892720-11-3
Molecular Weight 385.31
Formel C₁₇H₁₈Cl₂N₂O₂S
SMILES

O=C(N1CCC(C)(CC1)N)C2=CC=C(SC3=C(Cl)C(Cl)=CC=C3)O2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chengchun Zhu, et al. Design, Synthesis and Antitumor Activity of a Novel Class of SHP2 Allosteric Inhibitors with a Furanyl Amide-Based Scaffold. J Med Chem. 2024 Aug 8;67(15):13305-13323. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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