2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. SDUY038

SDUY038 is a SHP2 allosteric inhibitor, with an IC50 of 1.2 μM and KD of 0.29 μM, respectively. SDUY038 exhibits pan-antitumor activity (IC50 = 7-24 μM) by suppressing pERK expression. SDUY038 exhibits t1/2 of 3.95 h by oral administration.

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SDUY038

SDUY038 Chemical Structure

CAS No. : 2892720-11-3

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SDUY038 Related Antibodies

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Description

SDUY038 is a SHP2 allosteric inhibitor, with an IC50 of 1.2 μM and KD of 0.29 μM, respectively. SDUY038 exhibits pan-antitumor activity (IC50 = 7-24 μM) by suppressing pERK expression. SDUY038 exhibits t1/2 of 3.95 h by oral administration[1].

Cellular Effect
Cell Line Type Value Description References
4T1 IC50
7.3 μM
Compound: 21; SDUY038
Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
[PMID: 39066713]
5637 IC50
23.3 μM
Compound: 21; SDUY038
Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
[PMID: 39066713]
HCT-116 IC50
15.5 μM
Compound: 21; SDUY038
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
[PMID: 39066713]
HepG2 IC50
11.4 μM
Compound: 21; SDUY038
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
[PMID: 39066713]
MDA-MB-468 IC50
12.8 μM
Compound: 21; SDUY038
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
[PMID: 39066713]
RT-4 IC50
12.5 μM
Compound: 21; SDUY038
Antiproliferative activity against human RT-4 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human RT-4 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
[PMID: 39066713]
RT-4 IC50
5.1 μM
Compound: 21; SDUY038
Antitumor activity against human RT-4 cells cultured as organoids assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
Antitumor activity against human RT-4 cells cultured as organoids assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
[PMID: 39066713]
SW1990 IC50
11 μM
Compound: 21; SDUY038
Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
[PMID: 39066713]
SW480 IC50
9.9 μM
Compound: 21; SDUY038
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
[PMID: 39066713]
T-24 IC50
23.9 μM
Compound: 21; SDUY038
Antiproliferative activity against human T24 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human T24 cells assessed as inhibition of cell growth measured after 48 hrs by CCK-8 assay
[PMID: 39066713]
Molecular Weight

385.31

Formula

C17H18Cl2N2O2S
CAS No.
SMILES

O=C(N1CCC(C)(CC1)N)C2=CC=C(SC3=C(Cl)C(Cl)=CC=C3)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SDUY038 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDUY0382892720-11-3SDUY 038SDUY-038SHP2Src homology phosphatase 2PTPN11pERKtumorInhibitorinhibitorinhibit

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