Zidebactam (Synonyms: WCK-5107)

Name: Zidebactam
Brand: MedChemExpress
SKU: HY-120859
Rating: 5.0 (10 reviews)

Cat. No.: HY-120859 Pureza: 98.55%: Ficha de datos
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Zidebactam (WCK-5107) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC₅₀ of 0.26 μg/mL.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS : 1436861-97-0

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 10 publication(s) in Google Scholar

Other Forms of Zidebactam:

Zidebactam sodium salt Obtener un presupuesto
Zidebactam (Standard) Obtener un presupuesto

10 Publications Citing Use of MCE Zidebactam

Cell Proliferation/Viability Assay

: Zidebactam purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Sep 29;15(1):33616. [Abstract]; Zidebactam (0.125-0.5 µg/mL) had a potent antibacterial effect on four E. coli strains.

: Zidebactam purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2021 Nov 3;10(11):1341.; time–kill curves of Zidebactam (ZID) (0.5 µg/mL; 24 h) on C. amalonaticus N18 and K. pneumoniae KL 12 SG.

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•Related Screening Libraries:

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Ver todos los productos específicos de isoformas Beta-lactamase:

Ver todas las isoformas

Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

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Referencias
Revisión del cliente

Descripciòn

Zidebactam (WCK-5107) is a potent β-lactamase inhibitor^[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC₅₀ of 0.26 μg/mL^[2].

IC₅₀ & Target

IC50: 0.26 μg/mL (P. aeruginosa PAO1 PBP2)^[2]

In Vitro

Zidebactam (WCK-5107) inhibits WT Enterobacteriaceae with a MIC₅₀ of 0.25 mg/L. Zidebactam alone exhibits variable activity when tested against E. coli (MIC_50/90 0.12/0.12 mg/L) and Enterobacter spp. (MIC_50/90 0.12/0.25 mg/L)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

Peso molecular

391.40

Fòrmula

C₁₃H₂₁N₅O₇S

No. CAS

1436861-97-0

Appearance

Solid

Color

White to yellow

SMILES

O=C([C@@H]1CCCNC1)NNC([C@@H]2CC[C@@H]3C[N@]2C(N3OS(=O)(O)=O)=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (255.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (255.49 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5549 mL	12.7747 mL	25.5493 mL
5 mM	0.5110 mL	2.5549 mL	5.1099 mL
10 mM	0.2555 mL	1.2775 mL	2.5549 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 3

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.98 mg/mL (5.06 mM); Clear solution

This protocol yields a clear solution of ≥ 1.98 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (19.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (255.49 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 98.55%

Select Batch:

Ficha de datos (278 KB) SDS (252 KB)

COA (253 KB) HNMR (265 KB) LCMS (87 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Sader HS, et al. WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1696-1703. [Content Brief]

[2]. Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6). [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.5549 mL	12.7747 mL	25.5493 mL	63.8733 mL
	5 mM	0.5110 mL	2.5549 mL	5.1099 mL	12.7747 mL
	10 mM	0.2555 mL	1.2775 mL	2.5549 mL	6.3873 mL
	15 mM	0.1703 mL	0.8516 mL	1.7033 mL	4.2582 mL
	20 mM	0.1277 mL	0.6387 mL	1.2775 mL	3.1937 mL
	25 mM	0.1022 mL	0.5110 mL	1.0220 mL	2.5549 mL
	30 mM	0.0852 mL	0.4258 mL	0.8516 mL	2.1291 mL
	40 mM	0.0639 mL	0.3194 mL	0.6387 mL	1.5968 mL
	50 mM	0.0511 mL	0.2555 mL	0.5110 mL	1.2775 mL
	60 mM	0.0426 mL	0.2129 mL	0.4258 mL	1.0646 mL
	80 mM	0.0319 mL	0.1597 mL	0.3194 mL	0.7984 mL
	100 mM	0.0255 mL	0.1277 mL	0.2555 mL	0.6387 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Zidebactam Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zidebactam1436861-97-0WCK-5107WCK5107WCK 5107Penicillin-binding protein (PBP)Beta-lactamaseBacterialβ-lactamaseInhibitorinhibitorinhibit

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Zidebactam (Synonyms: WCK-5107)

Revisión del cliente

Other Forms of Zidebactam:

Zidebactam Related Antibodies

10 Publications Citing Use of MCE Zidebactam

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Beta-lactamase:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Zidebactam Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Zidebactam Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

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SAFETY DATA SHEET (SDS)

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