2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. (S)-(-)-5-Fluorowillardiine (hydrochloride)

(S)-(-)-5-Fluorowillardiine (hydrochloride)  (Synonyms: (5S)-Fluorowillardiine hydrochloride; (S)-5-Fluorowillardiine hydrochloride)

製品番号: HY-16713A 純度: 99.03%
COA 取扱説明書 Technical Support

(S)-(-)-5-Fluorowillardiine ((5S)-Fluorowillardiine; (S)-5-Fluorowillardiine) hydrochloride is a potent, highly selective non-NMDA ionotropic glutamate receptor (iGluR, AMPA/Kainate receptor) agonist. (S)-(-)-5-Fluorowillardiine hydrochloride activates high-affinity AMPA-preferring receptors (EC50 = 0.70 μM) and low-affinity kainate-preferring receptors (EC50 = 170 μM), thereby inducing biphasic dose-dependent neurotoxicity/excitotoxicity. (S)-(-)-5-Fluorowillardiine hydrochloride is applicable to research related to schizophrenia, temporal lobe epilepsy, and bipolar disorder.

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(S)-(-)-5-Fluorowillardiine (hydrochloride)

(S)-(-)-5-Fluorowillardiine (hydrochloride) 構造式

CAS 番号 : 1321546-70-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 123 在庫あり
Solution
10 mM * 1 mL in Water USD 123 在庫あり
Solid
5 mg $112 在庫あり
10 mg $174 在庫あり
25 mg $390 在庫あり
50 mg $708 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

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Other Forms of (S)-(-)-5-Fluorowillardiine (hydrochloride):

(S)-(-)-5-Fluorowillardiine (hydrochloride) 関連抗体

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AMPA Receptor NMDA Receptor Kainate Receptor

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製品説明

(S)-(-)-5-Fluorowillardiine ((5S)-Fluorowillardiine; (S)-5-Fluorowillardiine) hydrochloride is a potent, highly selective non-NMDA ionotropic glutamate receptor (iGluR, AMPA/Kainate receptor) agonist. (S)-(-)-5-Fluorowillardiine hydrochloride activates high-affinity AMPA-preferring receptors (EC50 = 0.70 μM) and low-affinity kainate-preferring receptors (EC50 = 170 μM), thereby inducing biphasic dose-dependent neurotoxicity/excitotoxicity. (S)-(-)-5-Fluorowillardiine hydrochloride is applicable to research related to schizophrenia, temporal lobe epilepsy, and bipolar disorder[1][2][3].

IC50 & Target

AMPA Receptor

 

体外実験

(S)-(-)-5-Fluorowillardiine (10-100 μM; 24 h) hydrochloride induces > 90% neurotoxicity in primary cultured murine cortical neurones via a biphasic mechanism, with high-affinity component activity at AMPA receptors (EC50 = 0.70 μM) and low-affinity component activity at kainate receptors (EC50 = 170 μM)[1].
(S)-(-)-5-Fluorowillardiine (200 nM-60 μM) hydrochloride potently activates AMPA/kainate receptors on primary dissociated cultures of mouse embryonic hippocampal neurons with an equilibrium EC50 of 1.47 μM, induces strong desensitization (92.5%), exhibits cross-desensitization with other willardiine derivatives, and produces a prolonged inward tail current following agonist removal[2].
(S)-(-)-5-Fluorowillardiine (0.1 nM-1 mM; 2 h) hydrochloride binds to mouse GluK5 kainate receptor subunits expressed in Sf9 cell membranes with a Ki of 1.79 μM, and exhibits similar affinity for GluK5 and GluK1 subunits[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-(-)-5-Fluorowillardiine (hydrochloride) 関連抗体
分子量

253.62

分子式

C7H9ClFN3O4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CN1C=C(F)C(NC1=O)=O)=O.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 6.67 mg/mL (26.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9429 mL 19.7145 mL 39.4291 mL
5 mM 0.7886 mL 3.9429 mL 7.8858 mL
10 mM 0.3943 mL 1.9715 mL 3.9429 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.9429 mL 19.7145 mL 39.4291 mL 98.5727 mL
5 mM 0.7886 mL 3.9429 mL 7.8858 mL 19.7145 mL
10 mM 0.3943 mL 1.9715 mL 3.9429 mL 9.8573 mL
15 mM 0.2629 mL 1.3143 mL 2.6286 mL 6.5715 mL
20 mM 0.1971 mL 0.9857 mL 1.9715 mL 4.9286 mL
25 mM 0.1577 mL 0.7886 mL 1.5772 mL 3.9429 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S)-(-)-5-Fluorowillardiine (hydrochloride) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-(-)-5-Fluorowillardiine (hydrochloride)1321546-70-6(5S)-Fluorowillardiine(S)-5-FluorowillardiineiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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(S)-(-)-5-Fluorowillardiine (hydrochloride)
製品番号:
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