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  4. Acivicin

Acivicin  (Synonyms: AT-125; U-42126)

製品番号: HY-W016586
COA 取扱説明書

Molarity Calculator

Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Acivicin hydrochloride) usually boasts enhanced water solubility and stability.

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Acivicin 構造式

Acivicin 構造式

CAS 番号 : 42228-92-2

容量 在庫状況
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100 mg   お問い合わせ  
250 mg   お問い合わせ  
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This product is a controlled substance and not for sale in your territory.

Other 在庫あり Forms of Acivicin:

Other Forms of Acivicin:

Acivicin 関連抗体

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製品説明

Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

IC50 & Target

γ-glutamyl transpeptidase[1]
体外実験

Acivicin (AT-125; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acivicin 関連抗体
体内実験

Acivicin (AT-125; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[3]
Dosage: 5 mg/kg
Administration: IP; twice weekly (monday and wednesday)
Result: Reduced urinary γ-GT by 70-78%.
分子量

178.57

分子式

C5H7ClN2O3
CAS 番号
Appearance

Solid

Color

White to light yellow

SMILES

ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1
Structure Classification
Initial Source

Streptomyces sviceus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外: 

H2O : 6.67 mg/mL (37.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6000 mL 28.0002 mL 56.0004 mL
5 mM 1.1200 mL 5.6000 mL 11.2001 mL
10 mM 0.5600 mL 2.8000 mL 5.6000 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 98.26% ee.: 99.96%

COA (249 KB) HNMR (258 KB) RP-HPLC (255 KB) NP-HPLC (118 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.6000 mL 28.0002 mL 56.0004 mL 140.0011 mL
5 mM 1.1200 mL 5.6000 mL 11.2001 mL 28.0002 mL
10 mM 0.5600 mL 2.8000 mL 5.6000 mL 14.0001 mL
15 mM 0.3733 mL 1.8667 mL 3.7334 mL 9.3334 mL
20 mM 0.2800 mL 1.4000 mL 2.8000 mL 7.0001 mL
25 mM 0.2240 mL 1.1200 mL 2.2400 mL 5.6000 mL
30 mM 0.1867 mL 0.9333 mL 1.8667 mL 4.6667 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Acivicin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acivicin42228-92-2AT-125 U-42126AT125AT 125U42126U 42126U-42126Parasiteγ-glutamyltranspeptidaseGGTblood-brainbarrierInhibitorinhibitorinhibit

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