1. Anti-infection
  2. Parasite
  3. Acivicin hydrochloride

Acivicin hydrochloride (Synonyms: AT-125 hydrochloride; U-42126 hydrochloride)

Cat. No.: HY-W016586A Purity: 99.08% ee.: 100.00%
Handling Instructions

Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.

For research use only. We do not sell to patients.

Acivicin hydrochloride Chemical Structure

Acivicin hydrochloride Chemical Structure

CAS No. : 161922-40-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Acivicin hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

IC50 & Target

γ−glutamyl transpeptidase[1]

In Vitro

Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days; for 4 days) reduces urinary gamma-GT by 70-78%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[1]
Dosage: 5 mg/kg
Administration: IP; twice weekly (monday and wednesday); for 4 days
Result: Reduced urinary gamma-GT by 70-78%.
Molecular Weight

215.03

Formula

C₅H₈Cl₂N₂O₃

CAS No.

161922-40-3

SMILES

[H]Cl.ClC1=NO[[email protected]@]([[email protected]](N)C(O)=O)([H])C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AcivicinAT-125U-42126AT125AT 125U42126U 42126Parasiteγ?glutamyltranspeptidaseGGTblood-brainbarrierInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Acivicin hydrochloride
Cat. No.:
HY-W016586A
Quantity:
MCE Japan Authorized Agent: