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  3. Acivicin

Acivicin (Synonyms: AT-125; U-42126)

Cat. No.: HY-W016586 Purity: 98.26% ee.: 99.96%
Handling Instructions

Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties.

For research use only. We do not sell to patients.

Acivicin Chemical Structure

Acivicin Chemical Structure

CAS No. : 42228-92-2

Size Price Stock Quantity
10 mM * 1 mL in Water USD 295 In-stock
Estimated Time of Arrival: December 31
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].

IC50 & Target

γ-glutamyl transpeptidase[1]

In Vitro

Acivicin (AT-125; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Acivicin (AT-125; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[3]
Dosage: 5 mg/kg
Administration: IP; twice weekly (monday and wednesday)
Result: Reduced urinary γ-GT by 70-78%.
Molecular Weight

178.57

Formula

C₅H₇ClN₂O₃

CAS No.

42228-92-2

SMILES

ClC1=NO[[email protected]@]([[email protected]](N)C(O)=O)([H])C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)

Solvent & Solubility
In Vitro: 

H2O : 6.67 mg/mL (37.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6000 mL 28.0002 mL 56.0004 mL
5 mM 1.1200 mL 5.6000 mL 11.2001 mL
10 mM 0.5600 mL 2.8000 mL 5.6000 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.26% ee.: 99.96%

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Keywords:

AcivicinAT-125 U-42126AT125AT 125U42126U 42126U-42126Parasiteγ-glutamyltranspeptidaseGGTblood-brainbarrierInhibitorinhibitorinhibit

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Acivicin
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