42228-92-2
42228-92-2
Chemical Structure
Acivicin
Synonym(s): AT-125; U-42126
- CAS No.: 42228-92-2
- Formula:C5H7ClN2O3
- Molecular Weight:178.57
IUPAC Name: (S)-2-amino-2-((S)-3-chloro-4,5-dihydroisoxazol-5-yl)acetic acid
InChIKey: QAWIHIJWNYOLBE-OKKQSCSOSA-N
SMILES: ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1
Biological Activity: Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
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Acivicin | 99.94% | Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties. | ||||||||||||||||||||
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Acivicin (Standard) | ≥98% | Acivicin (Standard) (AT-125 (Standard)) is the analytical standard of Acivicin (HY-W016586). This product is intended for research and analytical applications. Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties. | ||||||||||||||||||||
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References
- [1]. Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26. [Content Brief]
- [2]. Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5. [Content Brief]
