2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. AF615

AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction.

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AF615

AF615 Chemische Struktur

CAS. Nr. : 122510-61-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
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Beschreibung

AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction[1].

Molekulargewicht

267.31

Formel

C10H13N5O2S
CAS. Nr.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(C1=NC=CN=C1)NNC(N2CCOCC2)=S
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 25 mg/mL (93.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7410 mL 18.7049 mL 37.4097 mL
5 mM 0.7482 mL 3.7410 mL 7.4819 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.55%

SDS (251 KB)

COA (251 KB) HNMR (164 KB) LCMS (102 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7410 mL 18.7049 mL 37.4097 mL 93.5244 mL
5 mM 0.7482 mL 3.7410 mL 7.4819 mL 18.7049 mL
10 mM 0.3741 mL 1.8705 mL 3.7410 mL 9.3524 mL
15 mM 0.2494 mL 1.2470 mL 2.4940 mL 6.2350 mL
20 mM 0.1870 mL 0.9352 mL 1.8705 mL 4.6762 mL
25 mM 0.1496 mL 0.7482 mL 1.4964 mL 3.7410 mL
30 mM 0.1247 mL 0.6235 mL 1.2470 mL 3.1175 mL
40 mM 0.0935 mL 0.4676 mL 0.9352 mL 2.3381 mL
50 mM 0.0748 mL 0.3741 mL 0.7482 mL 1.8705 mL
60 mM 0.0623 mL 0.3117 mL 0.6235 mL 1.5587 mL
80 mM 0.0468 mL 0.2338 mL 0.4676 mL 1.1691 mL
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AF615 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AF615122510-61-6AF 615AF-615DNA/RNA SynthesisCDT1/GemininGeminin-tCDT1Inhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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