122510-61-6

AF615 Chemical Structure
122510-61-6

Chemical Structure

AF615

  • CAS No.: 122510-61-6
  • Formula:C10H13N5O2S
  • Molecular Weight:267.31

SMILES: O=C(C1=NC=CN=C1)NNC(N2CCOCC2)=S

Biological Activity: AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction[1].

Cat. No. Product Name Purity Description Pricing
HY-171180 		AF615 99.55% AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction.
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