2. 天然物
  3. Disease Research Fields Plants Ketones, Aldehydes, Acids
  4. Liliaceae
  5.  A．Sativam L. var．Viviparum Regel
  6. Alliin

Alliin  (Synonyms: アリイン)

製品番号: HY-N0661 純度: 99.63%
COA 取扱説明書 Technical Support

Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities.

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Alliin

Alliin 構造式

CAS 番号 : 556-27-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 130 在庫あり
Solution
10 mM * 1 mL in Water USD 130 在庫あり
Solid
1 mg $56 在庫あり
5 mg $119 在庫あり
10 mg $202 在庫あり
20 mg $343 在庫あり
50 mg $550 在庫あり
100 mg $770 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 3 publication(s) in Google Scholar

Other Forms of Alliin:

Alliin 関連抗体

Top Publications Citing Use of Products

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製品説明

Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities[1][2].

体外実験

Alliin (0-160 μM, 2 h) reduces lipid accumulation and ameliorates the cAMP Levels in 1,3-DCP-induced HepG2 cells[1].
Alliin (0-160 μM, 23 h) inhibits the expression levels of proteins and genes (SREBP-1, FAS, SREBP-2 and HMGCR) involved in AMPK–SREBPs signaling pathway in HepG2 Cells[1].
Alliin (100 μM, 6 h) inhibits p38, JNK and ERK1/2 phosphorylation and blocks MAPKs-mediated NF-κB/AP-1/STAT-1 signal transducer to improve the inflammatory responses in LPS-stimulated RAW264.7 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alliin 関連抗体

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 10-1280 μM
Incubation Time: 24 h
Result: Decreased the cell viability at concentrations from 320 μM to 1280 μM.
Did not have cell toxicity at concentrations from 0 μM to 160 μM.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 0-160 μM
Incubation Time: 23 h
Result: Increased the expression of p-AMPK and decreased the protein expression of AMPK at concentrations of 80 μM and 160 μM.
Inhibited the protein expression of SREBP-1, FAS, SREBP-2 and HMGCR by 1,3-DCP-induced at concentrations of 80 μM and 160 μM.

Western Blot Analysis[2]

Cell Line: RAW264.7
Concentration: 100 μg/mL
Incubation Time: 6 h
Result: Inhibited the protein expression of iNOS, IL-1β, IL-6, and TNF-α, and the production of NO.
Suppressed the expression of iNOS, TNF-α, IL-1β, and IL-6 mRNAs.
Blocked JNK/ERK1/2-mediated transcriptional activation of PPARγ.
体内実験

Alliin (500 mg/kg, i.g., 10 days) ameliorates colon damage and spleen changes in DSS colitis mouse model through reduces pro-inflammatory cytokines (iNOS, TNF-α and IL-6) expression and inhibits the phosphorylation of ERK1/2, JNK, p38 and PPARγ[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS colitis mouse model[2]
Dosage: 500 mg/kg
Administration: i.g., 10 days
Result: Decrease hematochezia symptom and diarrhea symptom.
Improved weight loss.
Reduced colon injury and inflammatory cell infiltration, restored the structure of colon epithelial and crypt.
Reduced the expression of iNOS, TNF-α and IL-6 mRNAs.
分子量

177.22

分子式

C6H11NO3S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](C[S@](CC=C)=O)C(O)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

H2O : 250 mg/mL (1410.68 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6427 mL 28.2135 mL 56.4270 mL
5 mM 1.1285 mL 5.6427 mL 11.2854 mL
10 mM 0.5643 mL 2.8214 mL 5.6427 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (564.27 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.82%

COA (246 KB) HNMR (117 KB) RP-HPLC (206 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.6427 mL 28.2135 mL 56.4270 mL 141.0676 mL
5 mM 1.1285 mL 5.6427 mL 11.2854 mL 28.2135 mL
10 mM 0.5643 mL 2.8214 mL 5.6427 mL 14.1068 mL
15 mM 0.3762 mL 1.8809 mL 3.7618 mL 9.4045 mL
20 mM 0.2821 mL 1.4107 mL 2.8214 mL 7.0534 mL
25 mM 0.2257 mL 1.1285 mL 2.2571 mL 5.6427 mL
30 mM 0.1881 mL 0.9405 mL 1.8809 mL 4.7023 mL
40 mM 0.1411 mL 0.7053 mL 1.4107 mL 3.5267 mL
50 mM 0.1129 mL 0.5643 mL 1.1285 mL 2.8214 mL
60 mM 0.0940 mL 0.4702 mL 0.9405 mL 2.3511 mL
80 mM 0.0705 mL 0.3527 mL 0.7053 mL 1.7633 mL
100 mM 0.0564 mL 0.2821 mL 0.5643 mL 1.4107 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Alliin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alliin556-27-4OthersHypoglycemicantioxidantanti-inflammatoryantitumororally activeHepG2 cellsRAW264.7Inhibitorinhibitorinhibit

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