2. Others Apoptosis
  3. Ferroptosis Environmental Pollutants
  4. Ammonium iron(III) citrate

Ammonium iron(III) citrate  (Synonyms: Ammonium ferric citrate; FAC; フレーザーリステリア鉄(III))

製品番号: HY-B1645 純度: 98.0%
COA 取扱説明書 Technical Support

Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production.

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CAS 番号 : 1185-57-5

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Based on 28 publication(s) in Google Scholar

Other Forms of Ammonium iron(III) citrate:

Ammonium iron(III) citrate 関連抗体

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
WB
Bio/Physico-chemical Assay
Cell Imaging/Staining

    Ammonium iron(III) citrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 7:e18323.  [Abstract]

    Immunoblot analysis of FDX1 and mitochondrial marker TOMM20 in OSRC2 cells treated for 24 h with either FAC (Ammonium iron(III) citrate) 0–4 μM.

    Ammonium iron(III) citrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 May 21:e2505359.  [Abstract]

    Ferroptosis was induced by erastin or FAC (Ammonium iron(III) citrate; 0-1600 μM) with different doses, and cell viability was analyzed by the CCK-8 after cells were treated for 2 days.

    Ammonium iron(III) citrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 May 21:e2505359.  [Abstract]

    Intracellular ROS was assessed using the DCFH-DA probe after being treated with 30 µM erastin or 500 µM FAC (Ammonium iron(III) citrate) for 4 h.

    Ammonium iron(III) citrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 May 21:e2505359.  [Abstract]

    Intracellular Fe2+ levels under 30 µM erastin or 500 µM FAC (Ammonium iron(III) citrate) treatment for 4 h were detected with the RhoNox-1(1μM; 1 h) fluorescent probe.

    Ammonium iron(III) citrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 May 21:e2505359.  [Abstract]

    Representative images of ferroptotic cells among iPSC-RPE cells, De-iPSC-RPE cells, and iRPE cells treated with 30 µM erastin or 500 µM FAC (Ammonium iron(III) citrate) for 2 days.

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    製品説明

    Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis[1]. Ammonium iron(III) citrate can enhance protein production[2].

    体外実験

    Ammonium iron(III) citrate (Ammonium ferric citrate; 1, 5, 10, 15 mM; 24 hours) with 5 mM induces cell death in HT1080 cells. AML12 cells were highly resistant to Ammonium iron(III) citrate, as they maintained cell viability about 80%. Ammonium iron(III) citrate can be actively transported into cells by specific transporter[1].
    Ammonium iron(III) citrate (6, 12, 18 mg/L) has a higher biomas for Chlorella vulgaris FSP-E (CV) in BG-11 medium with 12 mg/L and 18 mg/L[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ammonium iron(III) citrate 関連抗体
    臨床実験
    分子式

    C6H8O7.xFe.xH3N
    CAS 番号
    Appearance

    Solid

    Color

    Light brown to brown

    SMILES

    OC(CC(C(O)=O)(O)CC(O)=O)=O.[x Fe(III)].[x NH3]
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Store at room temperature, keep dry and cool

    *In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)
    溶剤 & 溶解度
    体外: 

    H2O : 33.33 mg/mL (Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

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    一般には略語で表示されます：C1V1 = C2V2

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    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL; Clear solution; Need ultrasonic

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 98.0%

    COA (253 KB) IR (143 KB)

    取扱説明書 (2659 KB)
    参考文献
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    Ammonium iron(III) citrate Related Classifications

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ammonium iron(III)1185-57-5Ammonium ferric FACFerroptosisEnvironmental PollutantsEnvironmental ContaminantsHT1080AML12ironInhibitorinhibitorinhibit

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    製品名:
    Ammonium iron(III) citrate
    製品番号:
    HY-B1645
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