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  4. Anti-Mouse GM-CSF Antibody (MP1-22E9)

Anti-Mouse GM-CSF Antibody (MP1-22E9) 

Cat. No.: HY-P99134 Purity: 95.49%
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Anti-Mouse GM-CSF Antibody (MP1-22E9) is a rat-derived anti-mouse GM-CSF IgG2a antibody inhibitor. Anti-Mouse GM-CSF Antibody (MP1-22E9) can neutralize GM-CSF. Anti-Mouse GM-CSF Antibody (MP1-22E9) can be used for the researches of cancer, infection inflammation and immunology, such as cholangiocarcinoma and arthritis.

For research use only. We do not sell to patients.

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Description

Anti-Mouse GM-CSF Antibody (MP1-22E9) is a rat-derived anti-mouse GM-CSF IgG2a antibody inhibitor. Anti-Mouse GM-CSF Antibody (MP1-22E9) can neutralize GM-CSF. Anti-Mouse GM-CSF Antibody (MP1-22E9) can be used for the researches of cancer, infection inflammation and immunology, such as cholangiocarcinoma and arthritis[1][2][3][4][5][6].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

GM-CSF
In Vitro

Anti-Mouse GM-CSF Antibody (MP1-22E9) (72 h) significantly reduces macrophage viability in bone marrow -derived macrophages[1].
Anti-Mouse GM-CSF Antibody (MP1-22E9) (10 μg/mL, 30 mins) promotes differentiation and migration in myeloid-derived suppressor cells[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse GM-CSF Antibody (MP1-22E9) Related Antibodies
In Vivo

Anti-Mouse GM-CSF Antibody (MP1-22E9) (30 mg/kg, i.p., every 2days for 4 week) inhibits progression of tumor and extended survival in autochthonous intrahepatic cholangiocarcinoma mice models[1].
Anti-Mouse GM-CSF Antibody (MP1-22E9) (800 μg, i.p., every monday and thursday for 2 weeks) decreases angiogenesis in L2/IKKβca mice[2].
Anti-Mouse GM-CSF Antibody (MP1-22E9) (250 μg, i.p., at the day before curdlan injection and twice weekly for 7 weeks or 9 days after disease triggering and twice weekly until day 28) inhibits bone marrow myelopoiesis and organ inflammation in spondyloarthritis mice models[3].
Anti-Mouse GM-CSF Antibody (MP1-22E9) (200 μg, i.p., every 3 days) inhibits antitumor immunity by neutralizing GM-CSF in B16F10-OVA tumor-bearing mice models[4].
Anti-Mouse GM-CSF Antibody (MP1-22E9) (100 μg, i.p., twice a week) shows anti-tumor effect in HM-1 tumor mice models[5].
Anti-Mouse GM-CSF Antibody (MP1-22E9) (250 μg, i.p., every other day beginning one day prior to infection for 3 times) shows anti-infection effect in clostridium difficile infected mice models[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Autochthonous intrahepatic cholangiocarcinoma mice models[1]
Dosage: 30 mg/kg
Administration: Intraperitoneally injection, every 2days for 4 weeks
Result: Suppressed tumor growth and increased latency to the development of multifocal liver tumours.
Significant reduced TAM infiltration and expression of ARG1 and PD-L1.
Significantly reduced circulating monocytes in the blood and elevated numbers of BM granulocytes.
Significantly reduced CFU in BM mononuclear cells and splenocytes.
Animal Model: L2/IKKβca mice[2]
Dosage: 800 μg
Administration: Intraperitoneally injection, every monday and thursday for 2 weeks
Result: Reduced the number of CD31+ blood vessels and VWF positive endothelial cells.
Animal Model: Spondyloarthritis mice models[3]
Dosage: 250 μg
Administration: Intraperitoneally injection, at the day before curdlan injection and twice weekly for 7 weeks or 9 days after disease triggering and twice weekly until day 28
Result: Decreased in LT-HSCs, MPPs and GMPs in the BM and increased CLPs cells.
Reducecd neutrophils and increased erythroid cells and B cells.
Decreased intestinal and articular neutrophil invasion.
Showed significant ameliorations in the histological and clinical scores of arthritis, marked decreases in enthesitis-associated ankle thickening and new bone formation, and inhibition of the bone surface:volume ratio increase.
Showed significant amelioration in enteritis and weight loss.
Animal Model: B16F10-OVA tumor-bearing mice models[4]
Dosage: 200 μg
Administration: Intraperitoneally injection, every 3 days
Result: Reduced the IL9-inducing capacity of moDCs and cDCs.
Increased or unaffected s IFNγ induction from naive or total CD4+ T cells.
Animal Model: HM-1 tumor mice models[5]
Dosage: 100 μg/mouse
Administration: Intraperitoneally injection, twice a week
Result: Suppressed tumor growth.
Decreased MDSCs.
Enhanced the efficacy of anti-VEGF abs.
Animal Model: Clostridium difficile infected mice models[6]
Dosage: 250 μg/mouse
Administration: Intraperitoneally injection, every other day beginning one day prior to infection for 3 times
Result: Showed lower C. difficile colonization levels and more modest weight loss.
Reduced IL-22 levels.
Resulted in significantly lower expression of IL-1β and TNFα.
Significantly reduced expression of the ELR+ CXC chemokines CXCL1 (KC) and CXCL2 (MIP-2).
Reduced neutrophils t in colonic mucosal sections and decreased iNOS expression.
Gene ID

12981  [NCBI]

Accession
Application

in vivo GM-CSF neutralization; in vitro GM-CSF neutralization; Flow cytometry
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse GM-CSF Antibody (MP1-22E9)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
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Purity & Documentation
References
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Anti-Mouse GM-CSF Antibody (MP1-22E9) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse GM-CSF Antibody (MP1-22E9)c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RGM-CSFCancerCholangiocarcinomaArthritisB16F10-OVAHM-1Clostridium difficileInhibitorinhibitorinhibit

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