Anti-Mouse IFNγR/CD119 Antibody (GR-20)

製品番号: HY-P990233 純度: ≥95.0%: Data Sheet SDS COA
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Anti-Mouse IFNγR/CD119 Antibody (GR-20) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IFNγR/CD119.Anti-Mouse IFNγR/CD119 Antibody (GR-20) reacts with the mouse IFNγR (interferon gamma receptor) α chain also known as CD119 and IFNγ receptor 1. Anti-Mouse IFNγR/CD119 Antibody (GR-20) blocks the binding of IFNγ to CD119 therefore inhibiting IFNγ signaling. Anti-Mouse IFNγR/CD119 Antibody (GR-20) can be used for the researches of cancer, infection, inflammation and immunology, such as melanoma and C. trachomatis infected genital tract inflammation.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Anti-Mouse IFNγR/CD119 Antibody (GR-20) 構造式

容量	価格（税別）	在庫状況	数量
1 mg	$200	在庫あり	Estimated Time of Arrival: December 31
5 mg	$650	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1050	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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製品説明

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

IFNγR/CD119

体外実験

Anti-Mouse IFNγR/CD119 Antibody (GR-20) (1 h) reduces non-classical MHC molecule Qa-1^b levels in B16 melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Anti-Mouse IFNγR/CD119 Antibody (GR-20) (200 μg, i.p., 1 day before infection and then every other day) promotess widespread genital tract inflammation and destruction in C. trachomatis infected mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C. trachomatis infected mice ^[2]
Dosage:	200 μg
Administration:	Intraperitoneally injection, 1 day before infection and then every other day
Result:	Showed widespread genital tract inflammation and destruction. Increased the frequency of IL-17-producing Chlamydia-specific CD4+ T cells. Dramatically increased the numbers of polymorphonuclear neutrophils and inflammatory monocytes.

Gene ID

15979 [NCBI]

Accession

P15261

Application

in vivo IFNγR neutralization; in vitro IFNγR neutralization

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IFNγR/CD119 Antibody (GR-20)]

Formulation

Please refer to the lot-specific COA for specific buffer information.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

純度: ≥95.0%

Select Batch:

データシート (261 KB) SDS (252 KB)

COA (233 KB)

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Montfoort N, et al. NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines. Cell. 2018 Dec 13;175(7):1744-1755.e15. [Content Brief]

[2]. Vicetti Miguel RD, et al. Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage. PLoS One. 2016 Sep 8;11(9):e0162445. [Content Brief]

Anti-Mouse IFNγR/CD119 Antibody (GR-20) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IFNγR/CD119 Antibody (GR-20)IFNARInterferon-α/β receptorInterferon-alpha/beta receptorIFNγCD119C. trachomatisMHCB16MelanomaGenital tract inflammationInhibitorinhibitorinhibit

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