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  5. Armenian Hamster Anti-Mouse CD80 Antibody (PE) (YA3448)

Armenian Hamster Anti-Mouse CD80 Antibody (PE) (YA3448)

Cat. No.: HY-P83711M
COA
SDS
User Guide for Antibodies Technical Support

Armenian Hamster Anti-Mouse CD80 Antibody (PE) (YA3448) is an Armenian hamster-derived and phycoerythrin (PE) IgG monoclonal antibody, targeting to CD80.

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Tamaño Precio Stock Cantidad
50 T En stock
100 T En stock
250 μL   Obtener un presupuesto  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Descripciòn

Descripciòn

Armenian Hamster Anti-Mouse CD80 Antibody (PE) (YA3448) is an Armenian hamster-derived and phycoerythrin (PE) IgG monoclonal antibody, targeting to CD80.
Host

Armenian hamster
Clonality

Monoclonal
Peso molecular
Predicted band size: 35 kDa;
Observed band size: 68 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Mouse
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from Mouse CD80.
Application &
Dilution Ratio
Application Dilution Ratio
FC
FC: Flow Cytometry
5μL per test for million cells or whole blood in 100 μL volume.
Pureza Affinity Purified Conjugation PE
Modification Unmodified Isotype IgG
Appearance

Liquid
Formulation

Supplied in PBS with 0.05% Proclin300, 1% BSA.
Storage & Stability

Stored at 2-8°C for 1 year, protect from light, do not freeze.
Envío

Shipping with blue ice.
Background
Function：Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:16339518). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (PubMed:22450810)
Subcellular Localization：Cell membrane; Single-pass type I membrane protein
Expression：
Tissue_specificity:It is expressed in activated B cells, interferon-gamma stimulated monocytes, and non-circulating B cells in malignant tumors.
Isoforms & Post-Translational Modification：Q00609 has 2 isomers: Q00609-1: 34590 Da (predicted); Q00609-2: 24051 Da (predicted).
Subunit：Homodimer. Interacts with CTLA4; this interaction inhibits T-cell activation. Interacts with PDL1/CD274; this interaction blocks PDL1/PDCD1 binding and thus PDL1 inhibitory function. Interacts with CD28
RRID
Database

Entrez Gene: 12519 Mouse

SwissProt: Q00609 Mouse

Synonyms
T-lymphocyte activation antigen CD80; Cd80; Activation B7-1 antigen; B7
Documentación
SDS (252 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

Armenian Hamster Anti-Mouse CD80 Antibody (PE) (YA3448) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nombre del producto:
Armenian Hamster Anti-Mouse CD80 Antibody (PE) (YA3448)
Cat. No.:
HY-P83711M
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