2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. AQ4

AQ4 is a topoisomerase II inhibitor and DNA intercalator as a chemically stable cytotoxic agent in many human tumor lines.

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AQ4

AQ4 Estructura química

No. CAS : 70476-63-0

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AQ4 Related Antibodies

Top Publications Citing Use of Products

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Ver todas las isoformas
Topoisomerase Topo I Topo II DNA gyrase

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Descripciòn

AQ4 is a topoisomerase II inhibitor and DNA intercalator as a chemically stable cytotoxic agent in many human tumor lines[1].

IC50 & Target

Topoisomerase II

 

Peso molecular

412.48

Fòrmula

C22H28N4O4
No. CAS
Appearance

Solid

Color

Brown to black

SMILES

O=C1C2=C(C(C3=C(C=CC(NCCN(C)C)=C13)NCCN(C)C)=O)C(O)=CC=C2O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 5 mg/mL (12.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4244 mL 12.1218 mL 24.2436 mL
5 mM 0.4849 mL 2.4244 mL 4.8487 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4244 mL 12.1218 mL 24.2436 mL 60.6090 mL
5 mM 0.4849 mL 2.4244 mL 4.8487 mL 12.1218 mL
10 mM 0.2424 mL 1.2122 mL 2.4244 mL 6.0609 mL
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AQ4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AQ470476-63-0AQ 4AQ-4TopoisomeraseInhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
AQ4
Cat. No.:
HY-121649
Cantidad:
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