Argininosuccinic acid

製品番号: HY-113149: Data Sheet 取扱説明書
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Argininosuccinic acid is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc.

It is advisable to consider the stable salt form (Argininosuccinic acid disodium) that retains the same biological activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Argininosuccinic acid 構造式

CAS 番号 : 2387-71-5

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other 在庫あり Forms of Argininosuccinic acid:

Argininosuccinic acid disodium

Other Forms of Argininosuccinic acid:

L-Argininosuccinic acid-¹³C₆,¹⁵N₄ barium, dihydrate 在庫あり
Argininosuccinic acid disodium 在庫あり

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

Argininosuccinic acid (250-1000 μM; 1 h) can reduce the concentration of reduced glutathione (GSH) and sulfhydryl content, increase the levels of malondialdehyde and carbonyl formation, induce protein oxidative damage, and promote the production of ROS in the cerebral cortex and striatum of rats in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Argininosuccinic acid (2 μM for 2 μL; intrastriatal administration; single dose) significantly induces oxidative stress in 30-day-old rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	30-day-old male Wistar rats^[1]
Dosage:	2 μL of a 1.0 M concentration (2 μM in 2 μL)
Administration:	Intrastriatal administration; single dose
Result:	Significantly induced lipid oxidation (MDA levels) and protein oxidation (carbonyl formation), increased ROS and RNS generation (DCFH oxidation). Significantly decreased GSH concentrations.

分子量

290.27

分子式

C₁₀H₁₈N₄O₆

CAS 番号

2387-71-5

SMILES

OC([C@@H](N)CCCNC(N[C@H](C(O)=O)CC(O)=O)=N)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Seminotti B, et al. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency? Mol Neurobiol. 2020 Feb;57(2):1233-1244. [Content Brief]

[2]. Erez A, et al. Argininosuccinate lyase deficiency-argininosuccinic aciduria and beyond. Am J Med Genet C Semin Med Genet. 2011 Feb 15;157C(1):45-53. [Content Brief]

[3]. Aoyagi K, et al. Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals. Free Radic Res. 1999 Jul;31(1):59-65. [Content Brief]