2387-71-5
Chemical Structure
Argininosuccinic acid
- CAS No.: 2387-71-5
- Formula:C10H18N4O6
- Molecular Weight:290.27
IUPAC Name: (N-((S)-4-amino-4-carboxybutyl)carbamimidoyl)-L-aspartic acid
InChIKey: KDZOASGQNOPSCU-WDSKDSINSA-N
SMILES: OC([C@@H](N)CCCNC(N[C@H](C(O)=O)CC(O)=O)=N)=O
Biological Activity: Argininosuccinic acid is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc[1][2][3].
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Argininosuccinic acid | Argininosuccinic acid is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc. | |||||||||||||||||||||
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L-Argininosuccinic acid-13C6,15N4 barium, dihydrate | 95.7% | L-Argininosuccinic acid-13C6,15N4 (barium, dihydrate) is a 15N-labeled and 13C-labled labeled L-Argininosuccinic acid (barium, dihydrate). | ||||||||||||||||||||
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- [1]. Seminotti B, et al. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency? Mol Neurobiol. 2020 Feb;57(2):1233-1244. [Content Brief]
- [2]. Erez A, et al. Argininosuccinate lyase deficiency-argininosuccinic aciduria and beyond. Am J Med Genet C Semin Med Genet. 2011 Feb 15;157C(1):45-53. [Content Brief]
- [3]. Aoyagi K, et al. Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals. Free Radic Res. 1999 Jul;31(1):59-65. [Content Brief]
