Argininosuccinic acid
Argininosuccinic acid is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc.
For research use only. We do not sell to patients.
- CAS No.: 2387-71-5
- Formula: C10H18N4O6
- Molecular Weight:290.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Argininosuccinic acid (250-1000 μM; 1 h) can reduce the concentration of reduced glutathione (GSH) and sulfhydryl content, increase the levels of malondialdehyde and carbonyl formation, induce protein oxidative damage, and promote the production of ROS in the cerebral cortex and striatum of rats in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:30-day-old male Wistar rats[1]
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Dosage:2 μL of a 1.0 M concentration (2 μM in 2 μL)
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Administration:Intrastriatal administration; single dose
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Result:Significantly induced lipid oxidation (MDA levels) and protein oxidation (carbonyl formation), increased ROS and RNS generation (DCFH oxidation).
Significantly decreased GSH concentrations.
Chemical Information
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CAS No. 2387-71-5
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Molecular Weight 290.27
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Formula C10H18N4O6
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SMILES
OC([C@@H](N)CCCNC(N[C@H](C(O)=O)CC(O)=O)=N)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Seminotti B, et al. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency? Mol Neurobiol. 2020 Feb;57(2):1233-1244. [Content Brief]
[2]. Erez A, et al. Argininosuccinate lyase deficiency-argininosuccinic aciduria and beyond. Am J Med Genet C Semin Med Genet. 2011 Feb 15;157C(1):45-53. [Content Brief]
[3]. Aoyagi K, et al. Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals. Free Radic Res. 1999 Jul;31(1):59-65. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Argininosuccinic acid Related Classifications
HY-113149 Related Classifications
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