2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. Aristolactam A IIIa

Aristolactam A IIIa  (Synonyms: Aristololactam A IIIa; Sch 546909)

Cat. No.: HY-N2892
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Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells.

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Aristolactam A IIIa

Aristolactam A IIIa Estructura química

No. CAS : 97399-91-2

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Aristolactam A IIIa Related Antibodies

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DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

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Descripciòn

Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells[1].

Cellular Effect
Cell Line Type Value Description References
B-cell IC50
19.2 μM
Compound: 6
Inhibition of LPS-induced BALB/c mouse B cell proliferation
Inhibition of LPS-induced BALB/c mouse B cell proliferation
[PMID: 17081761]
MCF7 IC50
3 μM
Compound: SCH-546909
Antiproliferative activity against human MCF7 cells by clonogenicity assay
Antiproliferative activity against human MCF7 cells by clonogenicity assay
[PMID: 20097066]
MCF7 IC50
> 10 nM
Compound: SCH-546909
Antiproliferative activity against human MCF7 cells by soft agar growth assay
Antiproliferative activity against human MCF7 cells by soft agar growth assay
[PMID: 20097066]
T-cell IC50
18.5 μM
Compound: 6
Inhibition of ConA-induced BALB/c mouse T cell proliferation
Inhibition of ConA-induced BALB/c mouse T cell proliferation
[PMID: 17081761]
Peso molecular

281.26

Fòrmula

C16H11NO4
No. CAS
SMILES

O=C1NC2=C3C1=CC(O)=C(OC)C3=C4C(C=CC(O)=C4)=C2
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Pureza y Documentación
Referencias
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Aristolactam A IIIa Related Classifications

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Keywords:

Aristolactam A IIIa97399-91-2Aristololactam A IIIa Sch 546909Sch546909Sch 546909Sch-546909DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseAAcollagenplatelet-activating factorPAFplatelet aggregationalkaloidHeLaInhibitorinhibitorinhibit

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