1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. BCI-215

BCI-215 

Cat. No.: HY-121087
Handling Instructions

BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells.

For research use only. We do not sell to patients.

BCI-215 Chemical Structure

BCI-215 Chemical Structure

CAS No. : 1245792-67-9

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Description

BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells[1][2].

IC50 & Target

DUSP-MKP[1]

In Vitro

BCI-215 concentration-dependently increases pERK levels in DUSP-overexpressing cells with IC50 value in the micromolar range[1].
BCI-215 (1-20 μM; 6 hours) retains fibroblast growth factor hyperactivating and cellular DUSP6/MKP-3 and DUSP1/MKP-1 inhibitory activity but is nontoxic to zebrafish embryos and an endothelial cell line[1].
BCI-215 inhibits survival and motility of MDA-MB-231 human breast cancer cells but does not affect viability of cultured hepatocytes[2].
BCI-215 is completely devoid of hepatocyte toxicity up to 100 µM[2].
BCI-215 does not generate ROS in hepatocytes or in developing Zebrafish larvae. BCI-215 (22 µM) has antimigratory and proapoptotic activities in breast cancer cells that correlate with induction of ERK phosphorylation[2].
BCI-215 (20 µM; 1 hour) induces mitogenic and stress signaling in cancer cells without generating ROS[2].

Apoptosis Analysis [2]

Cell Line: MDA-MB-231 cells
Concentration: 22 µM
Incubation Time:
Result: Caused apoptotic cell death at concentrations that induce ERK phosphorylation.

Western Blot Analysis[2]

Cell Line: MDA-MB-231 cells
Concentration: 20 µM
Incubation Time: 1 hour
Result: Induced a stress response that is not dependent on oxidation.
Molecular Weight

396.32

Formula

C₂₂H₂₂BrNO

CAS No.

1245792-67-9

SMILES

O=C1/C(C(NC2CCCCC2)C3=C1C=CC(Br)=C3)=C/C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BCI-215BCI215BCI 215PhosphatasedualspecificityMAPKphosphataseDUSP-MKPInhibitorinhibitorinhibit

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BCI-215
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