2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. Bcl-2-IN-10

Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research.

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Bcl-2-IN-10

Bcl-2-IN-10 Estructura química

No. CAS : 2773354-28-0

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Bcl-2-IN-10 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Bcl-2 Family:

Ver todas las isoformas
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Descripciòn

Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research[1].

IC50 & Target[1]

Bax

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
11.3 μM
Compound: 1
Anticancer activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
BT-474 IC50
7.06 μM
Compound: 1
Anticancer activity against human BT474 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human BT474 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
CCRF-CEM IC50
1.26 μM
Compound: 1
Anticancer activity against human CCRF-CEM cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human CCRF-CEM cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
Jurkat E6.1 IC50
1.94 μM
Compound: 1
Anticancer activity against human Jurkat E6-1 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human Jurkat E6-1 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
MDA-MB-231 IC50
17.86 μM
Compound: 1
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT or MTS assay
[PMID: 32156499]
In Vitro

Steroid sulfatase-IN-2 (compound 1, 0-20 μM approximately, 72 h) inhibits different cancer cells with IC50s ranging from 1.26 μM to 17.86 μM[1].
Steroid sulfatase-IN-2 (1 μM, 5 h) releases up to four molecules of nitric oxide[1].
Steroid sulfatase-IN-2 (8 μM, 8-72 h) induces leukemia cell CCRF-CEM apoptosis via MAPKs pathways, arrests cell in the G2/M phase, and increases ratio of Bax/Bcl-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bcl-2-IN-10 Related Antibodies

Apoptosis Analysis[1]

Cell Line: CEM cells
Concentration: 8 μM
Incubation Time: 8, 24, 48 or 72 h
Result: Induced apoptosis in a time-dependent and dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: CEM cells
Concentration: 8 μM
Incubation Time: 8, 24, 48 or 72 h
Result: Arrested cell in the G2/M phase.

Western Blot Analysis[1]

Cell Line: CEM cells
Concentration: 0-8 μM
Incubation Time: 72 h
Result: Increased the levels of JNK and p38, and the levels of phosphorylated JNK and p38.
Decreased Bcl-2 level in a time- and dose-dependent manner, and increased pro-apoptotic Bax level.
Peso molecular

635.50

Fòrmula

C22H25N11O12
No. CAS
SMILES

O=[N+](C1=CC([N+]([O-])=O)=C(C=C1)O/N=[N+](N2CCC(CC2)CN3CCN(CC3)/N=[N+](OC4=C(C=C(C=C4)[N+]([O-])=O)[N+]([O-])=O)\[O-])\[O-])[O-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Pureza y Documentación
Referencias
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Bcl-2-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-102773354-28-0Bcl-2 FamilyApoptosisDDNO derivativesanti-cancerNOapopotosisBax/Bcl-2MAPKInhibitorinhibitorinhibit

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Bcl-2-IN-10
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