2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. BMS493

BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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CAS No. : 215030-90-3

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Based on 6 publication(s) in Google Scholar

Other Forms of BMS493:

BMS493 Related Antibodies

Top Publications Citing Use of Products

    BMS493 purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Mar;58(3):e13762.  [Abstract]

    (F) Fluorescence microscopy images of MYL2-Venus hESCs reporter line-constructed RA and BMS493 (0.5 μM) treated groups on Day 21. Scale bar, 200 μm. (G) Histogram of flow cytometry analysis for MYL2-Venus hESCs reporter line-constructed RA and BMS493 (0.5 μM) treated groups on Day 21.

    BMS493 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Sep 29;13(9):838.  [Abstract]

    EdU and BMS493 (50 μl of 5 mM BMS493 ) were injected as described in A, and cryosections of the TA muscle from young and aged mice on D3 were stained for PAX7 and EdU. Arrows represent EdU+/PAX7+ cells; arrowheads represent EdU-/PAX7+ cells.

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    Description

    BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2]. BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

    In Vitro

    BMS493 (100 nM; 6 days; ALDHhi UCB cells) treatment shows a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. Newly expanded ALDHhi cells shows increased numbers of CD34 and CD133-positive cells, as well as a reduction in CD38 expression, a marker of hematopoietic cell differentiation[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    BMS493 Related Antibodies

    Cell Viability Assay[1]

    Cell Line: ALDHhi UCB cells
    Concentration: 100 nM
    Incubation Time: 6 days
    Result: Showed a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls.
    In Vivo

    Intrapancreatic transplantation of cell progeny after expansion of ALDHhi cells with or without BMS493 shows no reduction of hyperglycemia in Streptozotocin-treated NOD/SCID mice. Thus, Umbilical cord blood (UCB)-derived ALDHhi cells effectively lost islet regenerative capacity during ex vivo expansion[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Masse moléculaire

    404.50

    Formule

    C29H24O2
    CAS No.
    Appearance

    Solid

    SMILES

    O=C(O)C1=CC=C(/C=C/C2=CC=C3C(C)(C)CC=C(C#CC4=CC=CC=C4)C3=C2)C=C1
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvant et solubilité
    In Vitro: 

    DMSO : 50 mg/mL (123.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4722 mL 12.3609 mL 24.7219 mL
    5 mM 0.4944 mL 2.4722 mL 4.9444 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    In Vivo Dissolution Calculator
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    Working solution concentration: mg/mL
    Pureté et documentation

    Purity: 99.73%

    SDS (251 KB)

    COA (250 KB) HNMR (471 KB) RP-HPLC (253 KB) LCMS (80 KB)

    Instruction de manipulation (2659 KB)
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.4722 mL 12.3609 mL 24.7219 mL 61.8047 mL
    5 mM 0.4944 mL 2.4722 mL 4.9444 mL 12.3609 mL
    10 mM 0.2472 mL 1.2361 mL 2.4722 mL 6.1805 mL
    15 mM 0.1648 mL 0.8241 mL 1.6481 mL 4.1203 mL
    20 mM 0.1236 mL 0.6180 mL 1.2361 mL 3.0902 mL
    25 mM 0.0989 mL 0.4944 mL 0.9889 mL 2.4722 mL
    30 mM 0.0824 mL 0.4120 mL 0.8241 mL 2.0602 mL
    40 mM 0.0618 mL 0.3090 mL 0.6180 mL 1.5451 mL
    50 mM 0.0494 mL 0.2472 mL 0.4944 mL 1.2361 mL
    60 mM 0.0412 mL 0.2060 mL 0.4120 mL 1.0301 mL
    80 mM 0.0309 mL 0.1545 mL 0.3090 mL 0.7726 mL
    100 mM 0.0247 mL 0.1236 mL 0.2472 mL 0.6180 mL
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    BMS493 Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    BMS493215030-90-3BMS 493BMS-493RAR/RXRRetinoic acid receptorsRetinoid X receptorsInverseretinoicaciddifferentiationregenerativeisletALDHhicorepressorInhibitorinhibitorinhibit

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