2. GPCR/G Protein
  3. Leukotriene Receptor
  4. Boc-Phe-Leu-Phe-Leu-Phe

Boc-Phe-Leu-Phe-Leu-Phe  (Synonyms: L-BOC2)

Cat. No.: HY-P3318 Purity: 98.10%
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Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel. Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098). Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology.

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Boc-Phe-Leu-Phe-Leu-Phe

Boc-Phe-Leu-Phe-Leu-Phe 화학구조

CAS No. : 73572-58-4

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Other Forms of Boc-Phe-Leu-Phe-Leu-Phe:

Boc-Phe-Leu-Phe-Leu-Phe Related Antibodies

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  • References

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제품 설명

Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel. Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098). Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology[1][2][3][4][5].

In Vitro

Boc-Phe-Leu-Phe-Leu-Phe (0-50 μg/mL) inhibits the sprouting of HUVEC spheroids induced by PDR vitreous in a three-dimensional fibrin gel[1].
Boc-Phe-Leu-Phe-Leu-Phe (0-120 μM, 24 h) inhibits the sprouting of HUVEC spheroids mediated by VEGF in a dose-dependent manner[2].
Boc-Phe-Leu-Phe-Leu-Phe (100 ng/mL, 24 h) inhibits the ability of Ac2-26 (HY-P1098) to reduce the expression of TGF-β1, IL-1β, and IL-6 in LPS (HY-D1056)-induced RAW264.7 cells[4].
Boc-Phe-Leu-Phe-Leu-Phe (100 ng/mL, 24 h) blocks the inhibitory effect of Ac2-26 on the expression of α-SMA, collagen I, CTGF, and β-catenin in LPS-induced hepatic stellate cells (HSCs)[4].
Boc-Phe-Leu-Phe-Leu-Phe (10 µM) blocks the inhibitory effect of Ac2-26 on the increase of AnxA1 protein expression, phosphorylated NF-κB p65 levels, IκB-α degradation, and IL-8 production in A549 cells[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-Phe-Leu-Phe-Leu-Phe Related Antibodies

Real Time qPCR[4]

Cell Line: LPS (HY-D1056)-induced RAW264.7 cells
Concentration: 100 ng/mL
Incubation Time: 24 h
Result: Reduced the expression of TGF-β1, IL-1β, and IL-6.

Western Blot Analysis[4]

Cell Line: LPS (HY-D1056)-induced RAW264.7 cells
Concentration: 100 ng/mL
Incubation Time: 24 h
Result: Reduced the expression of α-SMA, collagen I, CTGF, and β-catenin.
In Vivo

Boc-Phe-Leu-Phe-Leu-Phe (1 mg/kg, intraperitoneal injection, twice weekly for 4-8 weeks) reverses the anti-inflammatory and antifibrotic effects of Ac2-26 in wild-type mice and AnxA1 knockout mice with CCl4-induced liver fibrosis[4].
Boc-Phe-Leu-Phe-Leu-Phe (50 µg per rat, intraperitoneal injection 30 min before surgery, single dose) reverses the protective effects of Ac2-26 in rats with ischemia-reperfusion-induced acute lung injury[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-to-eight-week-old C57BL/6 wild-type mice and C57BL/6JGpt Anxa1-KO mice (weighing 18-25 g) were given intraperitoneal injection of 20% CCl4 (500 mL) twice weekly to induce liver fibrosis[4]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection, twice weekly for 4/8 weeks
Result: Induced more severe liver lesions in CCl4-induced wild-type and AnxA1 knockout mice compared to Ac2-26 treatment, with lighter liver color, rougher surface, more nodules, and harder texture.
Increased liver inflammation and collagen deposition, as well as elevated expression of α-SMA, collagen I, CTGF, TGF-β1, IL-1β, IL-6, and β-catenin in liver tissues.
Reversed the anti-inflammatory and antifibrotic effects of Ac2-26, with the degree of liver damage and fibrosis similar to that in the CCl4-induced model group without Ac2-26 treatment.
Animal Model: Sprague-Dawley rats (male, 350 ± 20 g) were used to establish an isolated perfused lung model, with ischemia induced by stopping ventilation and perfusion for 40 min, followed by reperfusion for 60 min to induce ischemia-reperfusion lung injury[5]
Dosage: 50 µg per rat
Administration: Intraperitoneal injection 30 min before surgery for a single dose
Result: Abolished the protective effects of Ac2-26 in ischemia-reperfusion-induced acute lung injury in Sprague-Dawley rats, resulting in more severe lung edema, higher pulmonary arterial pressure, and increased protein concentration in bronchoalveolar lavage fluid.
Enhanced neutrophil infiltration, elevated levels of pro-inflammatory cytokines (CINC-1, TNF-α) in bronchoalveolar lavage fluid, and increased oxidative stress (higher protein carbonyl content and MDA level) and apoptosis (more activated caspase-3-immunolabeled cells, lower Bcl-2 expression) in lung tissue.
Aggravated lung tissue damage, with increased lung injury scores, disrupted tight junction proteins (claudin-3, occludin, ZO-1) in alveolar walls, and reversed the inhibition of NF-κB and MAPK pathways activation by Ac2-26.
분자량

785.97

화학식

C44H59N5O8
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Boc}-Phe-Leu-Phe-Leu-Phe
Sequence Shortening

{Boc}-FLFLF
선적

Room temperature in continental US; may vary elsewhere.
보관

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

순도&문서
References
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Boc-Phe-Leu-Phe-Leu-Phe Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-Phe-Leu-Phe-Leu-Phe73572-58-4L-BOC2Leukotriene Receptorleukotrienesvascular endothelial growth factorInhibitorinhibitorinhibit

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Boc-Phe-Leu-Phe-Leu-Phe
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HY-P3318
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