(S,S)-BRL-37344 sodium

Name: (S,S)-BRL-37344 sodium
Brand: MedChemExpress
SKU: HY-101325
Rating: 4.5 (0 reviews)

Cat. No.: HY-101325 Pureza: 99.90%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

(S,S)-BRL-37344 sodium is an isomer of BRL-37344 (HY-101325B). BRL-37344 is a β-adrenoceptor agonist with EC₅₀ values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes.

Para uso exclusivo en investigación. No vendemos a pacientes.

(S,S)-BRL-37344 sodium Estructura química

No. CAS : 127299-93-8

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto
50 mg	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Other Forms of (S,S)-BRL-37344 sodium:

(S,S)-BRL-37344 In-stock
BRL-37344 Obtener un presupuesto

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Adrenergic Receptor:

Ver todas las isoformas

α adrenergic receptor β adrenergic receptor

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

β adrenergic receptor

In Vitro

(S,S)-BRL-37344 sodium shows EC₅₀ >1000 nM forβ3, β2 and β1^[1].
(S,S)-BRL-37344 sodium does not induce concentration-dependent increases in atria1 rate and weakly induces relaxation of guinea pig trachea^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Animal Model:	Five-week-old male Imprinting Control Region (ICR) mice^[1]
Dosage:	2.5 mg/kg
Administration:	Intraperitoneal injection; three times per week for two weeks
Result:	Lowered the body weight of obese mice.

Peso molecular

385.82

Fòrmula

C₁₉H₂₁ClNNaO₄

No. CAS

127299-93-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])COC1=CC=C(C[C@@H](NC[C@H](C2=CC=CC(Cl)=C2)O)C)C=C1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 5 mg/mL (12.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5919 mL	12.9594 mL	25.9188 mL
5 mM	0.5184 mL	2.5919 mL	5.1838 mL
10 mM	0.2592 mL	1.2959 mL	2.5919 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 10 mg/mL (25.92 mM); Clear solution; Need ultrasonic and warming

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.90%

Select Batch:

Ficha de datos (269 KB) SDS (252 KB)

COA (244 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Ida K, et al. Stereoselective action of (R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl)ethylamino] propyl]-phenoxyacetic acid (BRL37344) on beta-adrenoceptors and metabolic chiral inversion. Biochem Pharmacol. 1996;52(10):1521-1527.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5919 mL	12.9594 mL	25.9188 mL	64.7971 mL
	5 mM	0.5184 mL	2.5919 mL	5.1838 mL	12.9594 mL
	10 mM	0.2592 mL	1.2959 mL	2.5919 mL	6.4797 mL