2. Epigenetics
  3. Histone Acetyltransferase
  4. Butyrolactone 3

Butyrolactone 3  (Synonyms: MB-3)

製品番号: HY-129039 純度: 99.58%
COA 取扱説明書 Technical Support

Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases.

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CAS 番号 : 778649-18-6

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
5 mg $188 在庫あり
10 mg $300 在庫あり
25 mg $600 在庫あり
50 mg $1000 在庫あり
100 mg $1400 在庫あり
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500 mg   お問い合わせ  

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カスタマーレビュー

Based on 11 publication(s) in Google Scholar

Butyrolactone 3 関連抗体

Top Publications Citing Use of Products

    Butyrolactone 3 purchased from MedChemExpress. Usage Cited in: Immunotargets Ther. 2025 Dec 28:14:1515-1529.  [Abstract]

    HE staining image of r renal tissues in sham-treated and I/R-treated C57BL/6 mice in the presence or absence of Butyrolactone 3 (10 mg/kg, iv).

    Butyrolactone 3 purchased from MedChemExpress. Usage Cited in: Immunotargets Ther. 2025 Dec 28:14:1515-1529.  [Abstract]

    PAS staining image of kidney from sham-treated and I/R-treated C57BL/6 mice in the presence or absence of Butyrolactone 3 (10 mg/kg, iv).

    Butyrolactone 3 purchased from MedChemExpress. Usage Cited in: Immunotargets Ther. 2025 Dec 28:14:1515-1529.  [Abstract]

    Masson’s trichrome staining in the renal cortex from sham-treated and I/R-treated C57BL/6 mice in the presence or absence of Butyrolactone 3 (10 mg/kg, iv)

    Butyrolactone 3 purchased from MedChemExpress. Usage Cited in: Immunotargets Ther. 2025 Dec 28:14:1515-1529.  [Abstract]

    The expression of KAT2A and F4/80 proteins in kidney tissue of IR-AKI mice was up-regulated by uIRI treatment, and significantly decreased after Butyrolactone 3 (10 mg/kg, iv) treatment.

    Butyrolactone 3 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jul 9:e2406333.  [Abstract]

    H1299 cells were treated with Lactate (20 mM), A-485, KAT8-IN-1 (300 µM), NU9056 (2 µM), Butyrolactone 3 (MB-3, 300 µM), or Gln-AMS (10 µM) for 14 h. Quantitative analysis of extracellular FFAs was conducted post-treatment.

    Butyrolactone 3 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Apr 30;13(4):421.  [Abstract]

    Effects of GCN5 inhibitor Butyrolactone 3 on binding of TAK1 with TAB1 and TAB2 in NRCMs under PE treatment.

    Histone Acetyltransferase アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases[1][2][3].

    IC50 & Target[1]

    GCN5

    100 μM (IC50)

    体外実験

    Butyrolactone 3 (50, 100, 200 μM, 16 h) can reduce acetylation of Gcn5 and induce degradation of E2A-PBX1[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Butyrolactone 3 関連抗体

    Western Blot Analysis[3]

    Cell Line: RCH-ACV
    Concentration: 50, 100, 200 μM
    Incubation Time: 16 h
    Result: Decreased the protein levels of E2A-PBX1 and E2A in a dose-dependent manner.
    Reduced Wnt16 and GCN5 protein levels.
    分子量

    184.19

    分子式

    C9H12O4
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C([C@@H](C1=C)[C@@H](CCC)OC1=O)O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years

    *The compound is unstable in solutions, freshly prepared is recommended.
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (542.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.4292 mL 27.1459 mL 54.2918 mL
    5 mM 1.0858 mL 5.4292 mL 10.8584 mL
    10 mM 0.5429 mL 2.7146 mL 5.4292 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    体積 （開始）

    V1

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (11.29 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (11.29 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *The compound is unstable in solutions, freshly prepared is recommended.

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.58%

    COA (250 KB) HNMR (213 KB) LCMS (93 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 5.4292 mL 27.1459 mL 54.2918 mL 135.7294 mL
    5 mM 1.0858 mL 5.4292 mL 10.8584 mL 27.1459 mL
    10 mM 0.5429 mL 2.7146 mL 5.4292 mL 13.5729 mL
    15 mM 0.3619 mL 1.8097 mL 3.6195 mL 9.0486 mL
    20 mM 0.2715 mL 1.3573 mL 2.7146 mL 6.7865 mL
    25 mM 0.2172 mL 1.0858 mL 2.1717 mL 5.4292 mL
    30 mM 0.1810 mL 0.9049 mL 1.8097 mL 4.5243 mL
    40 mM 0.1357 mL 0.6786 mL 1.3573 mL 3.3932 mL
    50 mM 0.1086 mL 0.5429 mL 1.0858 mL 2.7146 mL
    60 mM 0.0905 mL 0.4524 mL 0.9049 mL 2.2622 mL
    80 mM 0.0679 mL 0.3393 mL 0.6786 mL 1.6966 mL
    100 mM 0.0543 mL 0.2715 mL 0.5429 mL 1.3573 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Butyrolactone 3 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Butyrolactone 3778649-18-6MB-3Butyrolactone3Butyrolactone-3MB3MB 3Histone AcetyltransferaseHATsHATGcn5Histone acetyltransferaseRCH-ACVInhibitorinhibitorinhibit

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    製品名:
    Butyrolactone 3
    製品番号:
    HY-129039
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