Chitin synthase inhibitor 2 

Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC₅₀ value of 0.09 mM and the K_i value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B^[1].

IC50: 0.09 mM; Ki: 0.12 mM^[1]

Chitin synthase inhibitor 2 (compound 2b) (0, 0.032, 0.126, and 0.25 mM) inhibits chitin synthase with inhibition constant K_i value of 0.12 mM and the inhibition percent (IP) of 78.3% at 0.3 mM^[1].
Chitin synthase inhibitor 2 (1-4 μg/mL) has excellent antifungal activity with MIC (minimum inhibitory concentration) values of 2, 4, 1, and 2 μg/mL against C. albicans (ATCC 76615), A. fumigatus (GIMCC 3.19), C. albicans (ATCC 90023), and A. flavus (ATCC 16870), respectively^[1].
Chitin synthase inhibitor 2 (128-512 g/mL) has no antibacterial activity against MRSA (N. 315), S. aureus (ATCC 25923), B. subtilis (ATCC 6633), C. coli (JM 109), P. aeruginosa (ATCC 9027), and B. proteus (ATCC 8427) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

349.38

C₂₀H₁₉N₃O₃

2416338-24-2

O=C(NC1C(NC2=C(C=CC=C2)C1)=O)/C=C/C(NC3=CC=CC(C)=C3)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li B, Shen Y, Wu H, Wu X, Yuan L, Ji Q. Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2020 Jun 1;195:112278.  [Content Brief]