Chlorin e6 trimethyl ester

Name: Chlorin e6 trimethyl ester
Brand: MedChemExpress
SKU: HY-137475
Rating: 4.5 (1 reviews)

製品番号: HY-137475 純度: 99.81%: Data Sheet SDS COA 取扱説明書
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Chlorin e6 trimethyl ester, a methyl pheophorbide-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT).

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Chlorin e6 trimethyl ester 構造式

CAS 番号 : 35038-32-5

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 91	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 91	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$65	在庫あり	Estimated Time of Arrival: December 31
10 mg	$100	在庫あり	Estimated Time of Arrival: December 31
25 mg	$195	在庫あり	Estimated Time of Arrival: December 31
50 mg	$310	在庫あり	Estimated Time of Arrival: December 31
100 mg	$500	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 1 publication(s) in Google Scholar

顧客検証

•Research Square Preprint. 2023 Jun 21.

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Chlorin e6 trimethyl ester, a methyl pheophorbide-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT)^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	>100 3 Compound: chlorin-e6-trimethyl ester	Dark toxicity in human HepG2 cells after overnight incubation by MTT assay Dark toxicity in human HepG2 cells after overnight incubation by MTT assay	[PMID: 26306981]
HepG2	IC₅₀	26.5 3 Compound: chlorin-e6-trimethyl ester	Photo cytotoxic activity against human HepG2 cells irradiated with 1.7 J/cm'2 light dose for 10 mins measured after overnight incubation by MTT assay Photo cytotoxic activity against human HepG2 cells irradiated with 1.7 J/cm'2 light dose for 10 mins measured after overnight incubation by MTT assay	[PMID: 26306981]
HepG2	IC₅₀	26.5 3 Compound: chlorin-e6-trimethyl ester	Photo cytotoxic activity against human HepG2 cells irradiated with 1.7 J/cm'2 light dose for 10 mins measured after overnight incubation by MTT assay Photo cytotoxic activity against human HepG2 cells irradiated with 1.7 J/cm'2 light dose for 10 mins measured after overnight incubation by MTT assay	[PMID: 26306981]
HepG2	IC₅₀	> 100 3 Compound: chlorin-e6-trimethyl ester	Dark toxicity in human HepG2 cells after overnight incubation by MTT assay Dark toxicity in human HepG2 cells after overnight incubation by MTT assay	[PMID: 26306981]

体内実験

Chlorin e6 trimethyl ester (5 mg/kg; i.p.) has no tumorcidal activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

638.75

分子式

C₃₇H₄₂N₄O₆

CAS 番号

35038-32-5

Appearance

Solid

Color

Brown to black

SMILES

O=C(OC)C/C(C(NC(/C=C1C(CC)=C2C)=C3C)=C3C(OC)=O)=C(N=C(/C=C(C(C)=C/4C=C)\NC4=C/C2=N/1)[C@H]5C)\[C@H]5CCC(OC)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 10 mg/mL (15.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5656 mL	7.8278 mL	15.6556 mL
5 mM	0.3131 mL	1.5656 mL	3.1311 mL
10 mM	0.1566 mL	0.7828 mL	1.5656 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.81%

Select Batch:

データシート (280 KB) SDS (393 KB)

COA (263 KB) HNMR (314 KB) LCMS (96 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Pandey RK, et, al. Chlorin and porphyrin derivatives as potential photosensitizers in photodynamic therapy. Photochemistry and Photobiology. 1991. 53(1):65-72.

[2]. Bauer D, et, al. Functionalization of chlorin e6 trimethylester towards potential amphiphilic photosensitizers for photodynamic therapy. Journal of Porphyrins and Phthalocyanines. 2019. 23(3): 243-250.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5656 mL	7.8278 mL	15.6556 mL	39.1389 mL
	5 mM	0.3131 mL	1.5656 mL	3.1311 mL	7.8278 mL
	10 mM	0.1566 mL	0.7828 mL	1.5656 mL	3.9139 mL
	15 mM	0.1044 mL	0.5219 mL	1.0437 mL	2.6093 mL