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Clemizole hydrochloride

HY-30234A

Clemizole hydrochloride

Clemizole hydrochloride Chemical Structure

Clemizole Hcl is a H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.

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10 mM * 1 mL in DMSO $57 In-stock
5 mg $52 In-stock
10 mg $80 In-stock
50 mg $300 In-stock
100 mg $480 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €56 In-stock
5 mg €51 In-stock
10 mg €78 In-stock
50 mg €294 In-stock
100 mg €470 In-stock
200 mg Get quote
500 mg Get quote

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Product name: Clemizole hydrochloride
Cat. No.: HY-30234A

Clemizole hydrochloride Data Sheet

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    Purity: 99.70%

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    DataSheet

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Biological Activity of Clemizole hydrochloride

Clemizole Hcl is a H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
IC50 Value: 8mM (NS4B) [1]
Target: H1 receptor; Anti-HCV
in vitro: Although significant, clemizole's antiviral effect is moderate (50% effective concentration of 8 microM against an HCV genotype 2a clone). Combinations of clemizole with either interferon, ribavirin, or the nucleoside (NM283) and nonnucleoside (HCV796) HCV polymerase inhibitors were additive [1]. The differences in the rodent and human pathways for clemizole metabolism were of importance, because the predominant human metabolite was found to have synergistic anti-HCV activity [2].
in vivo: Clemizole and reserpine treatment did not produce any modification of the dose-response curve to histamine [3].
Clinical trial: Safety and Tolerability Study of Clemizole Hydrochloride to Treat Hepatitis C in Subjects Who Are Treatment-Naive (CLEAN-1). NCT00945880. Phase 1
 

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 362.3 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₁₉H₂₁Cl₂N₃
CAS No 1163-36-6
Solvent & Solubility

DMSO: ≥ 3.6 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.7601 mL 13.8007 mL 27.6014 mL
5 mM 0.5520 mL 2.7601 mL 5.5203 mL
10 mM 0.2760 mL 1.3801 mL 2.7601 mL

Clinical Information of Clemizole hydrochloride

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
Clemizole hydrochloride Eiger BioPharmaceuticals Inc Hepatitis C virus infection 31-JUL-09 31-AUG-10 Phase 1 14-SEP-13

References on Clemizole hydrochloride

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