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Clemizole hydrochloride Chemical Structure
|Product name: Clemizole hydrochloride|
|Cat. No.: HY-30234A|
Clemizole Hcl is a H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
IC50 Value: 8mM (NS4B) 
Target: H1 receptor; Anti-HCV
in vitro: Although significant, clemizole's antiviral effect is moderate (50% effective concentration of 8 microM against an HCV genotype 2a clone). Combinations of clemizole with either interferon, ribavirin, or the nucleoside (NM283) and nonnucleoside (HCV796) HCV polymerase inhibitors were additive . The differences in the rodent and human pathways for clemizole metabolism were of importance, because the predominant human metabolite was found to have synergistic anti-HCV activity .
in vivo: Clemizole and reserpine treatment did not produce any modification of the dose-response curve to histamine .
Clinical trial: Safety and Tolerability Study of Clemizole Hydrochloride to Treat Hepatitis C in Subjects Who Are Treatment-Naive (CLEAN-1). NCT00945880. Phase 1
|M.Wt||362.3||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 3.6 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.7601 mL||13.8007 mL||27.6014 mL|
|5 mM||0.5520 mL||2.7601 mL||5.5203 mL|
|10 mM||0.2760 mL||1.3801 mL||2.7601 mL|
|Product Name||Sponsor Only||Condition||Start Date||End Date||Phase||Last Change Date|
|Clemizole hydrochloride||Eiger BioPharmaceuticals Inc||Hepatitis C virus infection||31-JUL-09||31-AUG-10||Phase 1||14-SEP-13|
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