2. Membrane Transporter/Ion Channel Neuronal Signaling
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  4. CNQX disodium

CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist. CNQX disodium blocks the expression of fear-potentiated startle in rats.

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CAS No. : 479347-85-8

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Based on 16 publication(s) in Google Scholar

Other Forms of CNQX disodium:

CNQX disodium Related Antibodies

Top Publications Citing Use of Products

    CNQX disodium purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2025 Jan 27;23(1):e3003011.  [Abstract]

    Sample traces of eEPSCs in the RSC-ACC projections with the perfusion of D-AP5 (50 μM), GYKI53655 (100 μM), and CNQX (20 μM) sequentially under the presence of picrotoxin (50 μM) (one-way RM ANOVA with Sidak multiple comparisons tests.

    CNQX disodium purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2025 Jan 27;23(1):e3003011.  [Abstract]

    Sample amplitude curve of eEPSCs in the RSC-ACC projections with the perfusion of D-AP5 (50 μM), GYKI53655 (100 μM), and CNQX (20 μM) sequentially under the presence of picrotoxin (50 μM) (one-way RM ANOVA with Sidak multiple comparisons tests.

    CNQX disodium purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2025 Jan 27;23(1):e3003011.  [Abstract]

    Averaged amplitude of eEPSCs in the RSC-ACC projections with the perfusion of D-AP5 (50 μM), GYKI53655 (100 μM), and CNQX (20 μM) sequentially under the presence of picrotoxin (50 μM) (one-way RM ANOVA with Sidak multiple comparisons tests.

    CNQX disodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 May 15;15(1):4122.  [Abstract]

    Light-evoked EPSCs in vCE L5a PCs were abolished after bath application of tetrodotoxin (TTX) but were then reintroduced following application of 4-Aminopyridine, indicating the monosynaptic nature of connections from V2 to vCE L5a. These restored responses were blocked by AMPA receptor antagonist CNQX.

    CNQX disodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 May 15;15(1):4122.  [Abstract]

    The light-evoked EPSCs were abolished by TTX and rescued by 4-AP, but severely attenuated by CNQX.

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    AMPA Receptor NMDA Receptor Kainate Receptor

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    Description

    CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist[1]. CNQX disodium blocks the expression of fear-potentiated startle in rats[5].

    IC50 & Target

    Kainate Receptor

     

    In Vitro

    CNQX disodium (FG9065 disodium; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
    CNQX disodium (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    CNQX disodium Related Antibodies
    In Vivo

    CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval[4].
    The bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX disodium causes a complete blockade at a dose of 0.5 μg[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rats weighing 180-200 g[4]
    Dosage: 0.75, 1.5, and 3 mg/kg
    Administration: IP; 20 min before testing
    Result: Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval.
    Masse moléculaire

    276.12

    Formule

    C9H2N4Na2O4
    CAS No.
    Appearance

    Solid

    Color

    Brown to red

    SMILES

    N#CC1=CC2=C([N-]C(C([N-]2)=O)=O)C=C1[N+]([O-])=O.[Na+].[Na+]
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvant et solubilité
    In Vitro: 

    DMSO : 10.53 mg/mL (38.14 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6216 mL 18.1081 mL 36.2161 mL
    5 mM 0.7243 mL 3.6216 mL 7.2432 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Pureté et documentation
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.6216 mL 18.1081 mL 36.2161 mL 90.5403 mL
    5 mM 0.7243 mL 3.6216 mL 7.2432 mL 18.1081 mL
    10 mM 0.3622 mL 1.8108 mL 3.6216 mL 9.0540 mL
    15 mM 0.2414 mL 1.2072 mL 2.4144 mL 6.0360 mL
    20 mM 0.1811 mL 0.9054 mL 1.8108 mL 4.5270 mL
    25 mM 0.1449 mL 0.7243 mL 1.4486 mL 3.6216 mL
    30 mM 0.1207 mL 0.6036 mL 1.2072 mL 3.0180 mL
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    CNQX disodium Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CNQX disodium479347-85-8FG9065 disodiumiGluRIonotropic glutamate receptorsAMPAkainatenon-NMDAfear-potentiatedstartleInhibitorinhibitorinhibit

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