2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-33

COX-2-IN-33 (compound 5f) is a COX-2 inhibitor (IC50=45.5 nM), as well as a potential anti-inflammatory agent. COX-2-IN-33 inhibits in vivo pro-inflammatory cytokine production and keep gastric safety.

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COX-2-IN-33

COX-2-IN-33 Estructura química

No. CAS : 3049405-60-6

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COX-2-IN-33 Related Antibodies

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Descripciòn

COX-2-IN-33 (compound 5f) is a COX-2 inhibitor (IC50=45.5 nM), as well as a potential anti-inflammatory agent. COX-2-IN-33 inhibits in vivo pro-inflammatory cytokine production and keep gastric safety[1].

IC50 & Target

IC50: 45.5 nM (COX-2)
Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
5.74 μM
Compound: 5f
Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs incubation by Griess analysis
Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs incubation by Griess analysis
[PMID: 37224762]
Peso molecular

479.80

Fòrmula

C20H13ClF3N5O4
No. CAS
SMILES

O=C(OCC1=[N+]([O-])ON=C1C2=CC=CC=C2)C3=NN(C4=CC=CC(C(F)(F)F)=C4)C(CCl)=N3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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COX-2-IN-33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-333049405-60-6COXCyclooxygenaseInhibitorinhibitorinhibit

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Nombre del producto:
COX-2-IN-33
Cat. No.:
HY-149355
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