2. GPCR/G Protein
    Neuronal Signaling
  3. Melanocortin Receptor
  4. [D-Trp8]-γ-MSH

[D-Trp8]-γ-MSH 

Cat. No.: HY-P1217 Purity: 99.95%
COA Handling Instructions

[D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[D-Trp8]-γ-MSH Chemical Structure

[D-Trp8]-γ-MSH Chemical Structure

CAS No. : 321351-81-9

Size Price Stock Quantity
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 540 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of [D-Trp8]-γ-MSH:

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Description

[D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis[1][2].

IC50 & Target

MC3R

 

Molecular Weight

1570.77

Appearance

Solid

Formula

C74H99N21O16S
CAS No.
Sequence

Tyr-Val-Met-Gly-His-Phe-Arg-{d-Trp}-Asp-Arg-Phe-Gly
Sequence Shortening

YVMGHFR-{d-Trp}-DRFG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (7.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6366 mL 3.1832 mL 6.3663 mL
5 mM 0.1273 mL 0.6366 mL 1.2733 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

[D-Trp8]-γ-MSH321351-81-9Melanocortin ReceptorMC Receptormelanocortin3MC3hMC3inflammatoryrheumatoidarthritiscolitisInhibitorinhibitorinhibit

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