Decanoyl-RVKR-CMK (Synonyms: DecRVKRcmk)

Name: Decanoyl-RVKR-CMK
Brand: MedChemExpress
SKU: HY-107760
Rating: 4.5 (1 reviews)

Cat. No.: HY-107760 Purity: 99.64%: Data Sheet
COA

SDS
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Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

Decanoyl-RVKR-CMK 화학구조

CAS No. : 150113-99-8

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Decanoyl-RVKR-CMK:

Decanoyl-RVKR-CMK TFA In-stock

1 Publications Citing Use of MCE Decanoyl-RVKR-CMK

•PLoS Pathog. 2023 Nov 10;19(11):e1011789. [Abstract]

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HIV HIV-1 HIV-2

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC₅₀	11.5 μM Compound: Dec-RVKR-CMK	Inhibition of furin in African green monkey Vero cells assessed as protection against Stx-induced toxicity incubated for 4 hrs prior to Stx challenge measured after 24 hrs by LDH assay Inhibition of furin in African green monkey Vero cells assessed as protection against Stx-induced toxicity incubated for 4 hrs prior to Stx challenge measured after 24 hrs by LDH assay	[PMID: 24359257]

In Vitro

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2_ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell^[1].
Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL.
Concentration:	35 and 70 µΜ.
Incubation Time:	7 days.
Result:	Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).

분자량

744.41

화학식

C₃₄H₆₆ClN₁₁O₅

CAS No.

150113-99-8

Appearance

Solid

Color

White to off-white

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (134.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3433 mL	6.7167 mL	13.4335 mL
5 mM	0.2687 mL	1.3433 mL	2.6867 mL
10 mM	0.1343 mL	0.6717 mL	1.3433 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.64%

Select Batch:

Data Sheet (271 KB) SDS (254 KB)

COA (244 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)

References

[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84. [Content Brief]

[2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3433 mL	6.7167 mL	13.4335 mL	33.5836 mL
	5 mM	0.2687 mL	1.3433 mL	2.6867 mL	6.7167 mL
	10 mM	0.1343 mL	0.6717 mL	1.3433 mL	3.3584 mL
	15 mM	0.0896 mL	0.4478 mL	0.8956 mL	2.2389 mL
	20 mM	0.0672 mL	0.3358 mL	0.6717 mL	1.6792 mL
	25 mM	0.0537 mL	0.2687 mL	0.5373 mL	1.3433 mL
	30 mM	0.0448 mL	0.2239 mL	0.4478 mL	1.1195 mL
	40 mM	0.0336 mL	0.1679 mL	0.3358 mL	0.8396 mL
	50 mM	0.0269 mL	0.1343 mL	0.2687 mL	0.6717 mL
	60 mM	0.0224 mL	0.1119 mL	0.2239 mL	0.5597 mL
	80 mM	0.0168 mL	0.0840 mL	0.1679 mL	0.4198 mL
	100 mM	0.0134 mL	0.0672 mL	0.1343 mL	0.3358 mL

Decanoyl-RVKR-CMK Related Classifications

Inflammation/Immunology Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Decanoyl-RVKR-CMK150113-99-8DecRVKRcmkHIVHuman immunodeficiency virusglycoproteinVGF glycoproteinVGFHIV-2 ROD infectionreplicationInhibitorinhibitorinhibit

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Decanoyl-RVKR-CMK (Synonyms: DecRVKRcmk)

고객리뷰

Other Forms of Decanoyl-RVKR-CMK:

Decanoyl-RVKR-CMK Related Antibodies

1 Publications Citing Use of MCE Decanoyl-RVKR-CMK

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All HIV Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Decanoyl-RVKR-CMK Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Decanoyl-RVKR-CMK Related Classifications

Keywords:

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고객리뷰

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SAFETY DATA SHEET (SDS)

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