2. Disease Areas
  3. Infection
  4. Viral Infection
  5. Flavivirus Infection

Flavivirus Infection

Flavivirus infections are caused by a group of single-stranded RNA viruses within the Flaviviridae family, primarily transmitted by mosquitoes and ticks, leading to significant global public health concerns. These infections include diseases such as Yellow Fever, Dengue, Japanese Encephalitis, and Zika virus infection, which can manifest as severe febrile illnesses, encephalitis, or hemorrhagic fever. Endemic in tropical and subtropical regions, particularly in Asia, the Americas, and parts of Africa, flaviviruses pose a major threat due to their potential for outbreaks and emerging variants. The immune response, especially humoral immunity, plays a critical role in protection against these infections. Notably, Zika virus is associated with congenital defects such as microcephaly, highlighting the broad clinical and epidemiological impact of this viral group.

Flavivirus Infection (10):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0381
    Maackiain 19908-48-6 99.83%
    Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB, mTOR, MAO-B, NFATc1 and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever。
    Maackiain
  • HY-137265
    Aminomethyltrioxsalen hydrochloride 62442-61-9 99.76%
    Aminomethyltrioxsalen hydrochloride is a psoralen derivative and nucleic acid intercalator. Aminomethyltrioxsalen hydrochloride can penetrate intact cells and react with nucleic acid secondary structures in vivo without disrupting the tissue structure of natural nucleoproteins. Aminomethyltrioxsalen hydrochloride inactivates viruses by crosslinking nucleic acid pyrimidine residues after exposure to UV-A radiation. Aminomethyltrioxsalen hydrochloride can be used in research related to dengue virus infection.
    Aminomethyltrioxsalen hydrochloride
  • HY-107586
    Demethylasterriquinone B1 78860-34-1 98.10%
    Demethylasterriquinone B1 (DAQ B1; L-783281) is an orally active insulin receptor (insulin receptor) agonist and AKT activator. By activating AKT, Demethylasterriquinone B1 upregulates the expression and activity of eNOS to increase NO production, while downregulating the expression of the NADPH oxidase subunit p22phox to reduce oxidative stress and improve vascular endothelial dysfunction in hypertensive rats. Demethylasterriquinone B1 combind with an AKT inhibitor targets the insulin signaling pathway to activate two antiviral pathways, RNA interference and JAK/STAT, in mosquitoes, thereby reducing Zika virus infection.
    Demethylasterriquinone B1
  • HY-18223
    NITD-203 1207518-71-5
    NITD-203 is a RdRp domain inhibitor. NITD 203 induces inhibition of the four DENV serotypes, as well as of YFV and WNV.
    NITD-203
  • HY-W006474
    γ-Carboline 244-69-9 99.86%
    γ-Carboline is a skeleton and antiviral agent. γ-Carboline shows anti-BVDV activity, with an EC50  of  2.0  μM. γ-Carboline derivatives show anti-BVDV, antibacterial, antifungal, antitumor activity.
    γ-Carboline
  • HY-183314
    ZIKV-IN-9
    ZIKV-IN-9 is a ZIKV inhibitor that blocks the early binding of viral particles to the cell surface. ZIKV-IN-9 inhibits ZIKV in various cell models. ZIKV-IN-9 is applicable to research related to Zika virus infection.
    ZIKV-IN-9
  • HY-125426
    ToP-DNJ 1508303-85-2
    ToP-DNJ is a selective endoplasmic reticulum α-glucosidase II (GluII) inhibitor with an IC50 value of 9.0 μM. ToP-DNJ selectively inhibits the two catalytic reactions of GluII, and exhibits stronger activity in the first step of converting di-glycosylated glycans to mono-glycosylated glycans. ToP-DNJ exhibits anti-DENV activity. ToP-DNJ can be used in studies related to dengue virus infection.
    ToP-DNJ
  • HY-181991
    IRBM-Z-2 3014840-61-7
    IRBM-Z-2 is a non-competitive, orally active Zika virus (ZIKV) NS2B-NS3 protease inhibitor, with IC50 values of 0.04 μM and 3.1 μM against the wild-type and I156T mutant strains, respectively. IRBM-Z-2 exhibits broad-spectrum anti-flavivirus potential, with IC50 values of 2.1 μM and 0.09 μM against the NS2B-NS3 proteases of dengue virus 2 (DENV2) and West Nile virus (WNV), respectively. IRBM-Z-1 inhibits ZIKV replication and alleviates virus-induced cytopathic effects. IRBM-Z-1 can be used in studies related to ZIKV infection.
    IRBM-Z-2
  • HY-156052
    CN-716 dihydrochloride 2077164-48-6
    CN-716 dihydrochloride is a reversible covalent flavivirus NS2B·NS3 protease inhibitor with antiviral activity. CN-716 dihydrochloride effectively inhibits the replication of dengue virus (DENV2), West Nile virus (WNV) and Zika virus (ZIKV). The IC50 values of CN-716 dihydrochloride against the proteases of the above three viruses are 0.066 μM, 0.11 μM and 0.25 μM, respectively, while the Ki values against the same proteases are 0.051 μM, 0.082 μM and 0.04 μM, respectively. CN-716 dihydrochloride can be used to study the infection mechanisms of dengue fever, West Nile fever and Zika virus infection.
    CN-716 dihydrochloride
  • HY-131379
    ZX-2401 67410-65-5
    ZX-2401 (Compound 98a) is a 1,3,5-Triazine-based analogue of Purine (HY-34431). ZX-2401 has a significant antiviral activity against viruses of the Flaviviridae family, such as West Nile Virus (WNV), Hepatitis C (HCV), Yellow Fever Virus (YFV), Dengue Virus (DV), Bovine Viral Diarrhea Virus (BVDV) and Banzi Virus (BV) with EC90s of 0.6-10 μg/mL. ZX-2401 significantly reduces virus production with an EC90 of 3.3 mg/mL. ZX-2401 can be used for influenza infections research.
    ZX-2401