Aminomethyltrioxsalen hydrochloride
Based on 1 publication(s) in Google Scholar
Aminomethyltrioxsalen hydrochloride is a psoralen derivative. Aminomethyltrioxsalen hydrochloride can penetrate intact cells and react with nucleic acid secondary structures in vivo without disrupting the tissue structure of natural nucleoproteins. Aminomethyltrioxsalen hydrochloride inactivates viruses by crosslinking nucleic acid pyrimidine residues after exposure to UV-A radiation. Aminomethyltrioxsalen hydrochloride can be used in research related to dengue virus infection.
For research use only. We do not sell to patients.
- Purity : 99.76%
- CAS No.: 62442-61-9
- Formula: C15H16ClNO3
- Molecular Weight:293.75
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Aminomethyltrioxsalen hydrochloride
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Biological Activity
Description
In Vitro
Aminomethyltrioxsalen hydrochloride (50 μg/mL; with UV irradiation) crosslinks double-stranded RNA purified from HeLa cell hnRNP particles in vitro, resulting in a 39.6% snapback fraction (4.4-fold increase over control)[1].
Aminomethyltrioxsalen hydrochloride (10 μg/mL) fully inactivates dengue-1 virus (Western Pacific 74 strain) propagated in Aedes albopticus C6/36 clonal cell culture[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Aotus nancymaae (adult, dengue-naïve, ≥700g mass)[2]
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Dosage:10 μg/mL
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Administration:added to DENV-1 cell culture supernatant; combined with UVA radiation (200 μW/cm2 for 10 minutes)
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Result:Successfully inactivated DENV-1, as confirmed by absence of plaque formation in BHK-21 cells.
Induced anti-DENV-1 IgG and neutralizing antibody responses in vaccinated monkeys.
Reduced mean days of viremia from 3.67 in control animals to 0.71 in vaccinated animals post-DENV-1 challenge.
Chemical Information
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CAS No. 62442-61-9
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Appearance Solid
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Molecular Weight 293.75
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Formula C15H16ClNO3
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Color White to light yellow
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SMILES
O=C1C=C(C)C2=CC3=C(OC(C)=C3CN)C(C)=C2O1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2026 Jul;655(8122):468-477. PMID: 42162425
Solvent & Solubility
In Vitro:
DMSO : 5.83 mg/mL (19.85 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2 mg/mL (6.81 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Handling Instructions (2659 KB)
References
[1]. Calvet JP, et al. Heterogeneous nuclear RNA double-stranded regions probed in living HeLa cells by crosslinking with the psoralen derivative aminomethyltrioxsalen. Proc Natl Acad Sci U S A. 1979;76(2):755-759. [Content Brief]
[2]. Maves RC, et al. Immunogenicity and protective efficacy of a psoralen-inactivated dengue-1 virus vaccine candidate in Aotus nancymaae monkeys. Vaccine. 2011;29(15):2691-2696. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.4043 mL | 17.0213 mL | 34.0426 mL | 85.1064 mL |
| 5 mM | 0.6809 mL | 3.4043 mL | 6.8085 mL | 17.0213 mL | |
| DMSO | 10 mM | 0.3404 mL | 1.7021 mL | 3.4043 mL | 8.5106 mL |
| 15 mM | 0.2270 mL | 1.1348 mL | 2.2695 mL | 5.6738 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Aminomethyltrioxsalen hydrochloride Related Classifications
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