Aminomethyltrioxsalen hydrochloride

Name: Aminomethyltrioxsalen hydrochloride
Brand: MedChemExpress
SKU: HY-137265
Rating: 4.5 (0 reviews)

Cat. No.: HY-137265 Purity: 99.76%: Data Sheet
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Aminomethyltrioxsalen hydrochloride is a psoralen derivative. Aminomethyltrioxsalen hydrochloride can penetrate intact cells and react with nucleic acid secondary structures in vivo without disrupting the tissue structure of natural nucleoproteins. Aminomethyltrioxsalen hydrochloride inactivates viruses by crosslinking nucleic acid pyrimidine residues after exposure to UV-A radiation. Aminomethyltrioxsalen hydrochloride can be used in research related to dengue virus infection.

For research use only. We do not sell to patients.

Aminomethyltrioxsalen hydrochloride Chemical Structure

CAS No. : 62442-61-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of Aminomethyltrioxsalen hydrochloride:

4'-Aminomethyl-4,5',8-trimethylpsoralen In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Aminomethyltrioxsalen hydrochloride (50 μg/mL; with UV irradiation) crosslinks double-stranded RNA purified from HeLa cell hnRNP particles in vitro, resulting in a 39.6% snapback fraction (4.4-fold increase over control)^[1].
Aminomethyltrioxsalen hydrochloride (10 μg/mL) fully inactivates dengue-1 virus (Western Pacific 74 strain) propagated in Aedes albopticus C6/36 clonal cell culture^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aminomethyltrioxsalen hydrochloride (10 μg/mL; added to DENV-1 cell culture supernatant; combined with UVA radiation (200 μW/cm² for 10 minutes)) in combination with UVA radiation effectively inactivates DENV-1 while preserving viral immunogenicity, leading to reduced viremia in vaccinated Aotus nancymaae monkeys following DENV-1 challenge^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Aotus nancymaae (adult, dengue-naïve, ≥700g mass)^[2]
Dosage:	10 μg/mL
Administration:	added to DENV-1 cell culture supernatant; combined with UVA radiation (200 μW/cm² for 10 minutes)
Result:	Successfully inactivated DENV-1, as confirmed by absence of plaque formation in BHK-21 cells. Induced anti-DENV-1 IgG and neutralizing antibody responses in vaccinated monkeys. Reduced mean days of viremia from 3.67 in control animals to 0.71 in vaccinated animals post-DENV-1 challenge.

Molecular Weight

293.75

Formula

C₁₅H₁₆ClNO₃

CAS No.

62442-61-9

Appearance

Solid

Color

White to light yellow

SMILES

O=C1C=C(C)C2=CC3=C(OC(C)=C3CN)C(C)=C2O1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 5.83 mg/mL (19.85 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 2 mg/mL (6.81 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4043 mL	17.0213 mL	34.0426 mL
5 mM	0.6809 mL	3.4043 mL	6.8085 mL
10 mM	0.3404 mL	1.7021 mL	3.4043 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.76%

Select Batch:

Data Sheet (275 KB) SDS (476 KB)

COA (251 KB) HNMR (257 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

References

[1]. Calvet JP, et al. Heterogeneous nuclear RNA double-stranded regions probed in living HeLa cells by crosslinking with the psoralen derivative aminomethyltrioxsalen. Proc Natl Acad Sci U S A. 1979;76(2):755-759. [Content Brief]

[2]. Maves RC, et al. Immunogenicity and protective efficacy of a psoralen-inactivated dengue-1 virus vaccine candidate in Aotus nancymaae monkeys. Vaccine. 2011;29(15):2691-2696. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.4043 mL	17.0213 mL	34.0426 mL	85.1064 mL
H₂O / DMSO	5 mM	0.6809 mL	3.4043 mL	6.8085 mL	17.0213 mL
DMSO	10 mM	0.3404 mL	1.7021 mL	3.4043 mL	8.5106 mL
DMSO	15 mM	0.2270 mL	1.1348 mL	2.2695 mL	5.6738 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.