2. Anti-infection
  3. Flavivirus
  4. ZIKV-IN-9

ZIKV-IN-9 is a ZIKV inhibitor that blocks the early binding of viral particles to the cell surface. ZIKV-IN-9 inhibits ZIKV in various cell models. ZIKV-IN-9 is applicable to research related to Zika virus infection.

For research use only. We do not sell to patients.

ZIKV-IN-9

ZIKV-IN-9 Chemical Structure

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ZIKV-IN-9 Related Antibodies

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Description

ZIKV-IN-9 is a ZIKV inhibitor that blocks the early binding of viral particles to the cell surface. ZIKV-IN-9 inhibits ZIKV in various cell models. ZIKV-IN-9 is applicable to research related to Zika virus infection[1].

In Vitro

ZIKV-IN-9 (compound 5v) (10 μM; 96 h) reduces ZIKV-induced cytopathic effect by 88.84% and maintains 88.91% cell viability in Vero cells[1].
ZIKV-IN-9 (96 h) potently inhibits ZIKV in Vero cells with an EC50 of 3.25 μM and no detectable cytotoxicity at tested concentrations[1].
ZIKV-IN-9 (24 h) inhibits ZIKV in A549 cells with an EC50 of 6.32 μM, a CC50 > 100 μM, and a selectivity index > 15[1].
ZIKV-IN-9 (10 μM; 24 h) inhibits ZIKV RNA synthesis and envelope protein expression in U251 cells, with an EC50 of 4.30 μM, a CC50 > 40 μM, and a selectivity index > 9[1].
ZIKV-IN-9 (5-20 μM; 24 h) potently inhibits both ZIKV MR766 and HPF2013 strains in A549 cells in vitro in a dose-dependent manner[1].
ZIKV-IN-9 (20 μM) mainly targets the early adsorption stage of the ZIKV life cycle in A549 cells and blocks viral particle attachment to the cell surface, confirming its function as a ZIKV entry inhibitor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZIKV-IN-9 Related Antibodies

Cell Viability Assay[1]

Cell Line: Vero cells (African green monkey kidney cells)
Concentration: 10 μM
Incubation Time: 96 h
Result: Reduced ZIKV-induced CPE by 88.84%.
Maintained 88.91% cell viability in uninfected Vero cells.

Cell Viability Assay[1]

Cell Line: Vero cells
Concentration: Log -0.5, Log 0, Log 0.5, Log 1, Log 1.5 μM
Incubation Time: 96 h
Result: Exhibited concentration-dependent protection against ZIKV-induced CPE.
Achieved an EC50 of 3.25 μM.
Showed no detectable cytotoxicity at tested concentrations.

Real Time qPCR[1]

Cell Line: U251 human glioblastoma cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Significantly suppressed ZIKV RNA synthesis at 10 μM.

Western Blot Analysis[1]

Cell Line: U251 human glioblastoma cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Significantly suppressed ZIKV envelope protein expression at 10 μM.

Real Time qPCR[1]

Cell Line: A549 human lung epithelial cells
Concentration: 5, 10, 20 μM
Incubation Time: 24 h
Result: Significantly reduced viral RNA replication across all tested concentrations.
Showed the strongest effects at 20 μM.

Western Blot Analysis[1]

Cell Line: A549 human lung epithelial cells
Concentration: 5, 10, 20 μM
Incubation Time: 24 h
Result: Significantly reduced envelope protein expression across all tested concentrations.
Showed the strongest effects at 20 μM.

Real Time qPCR[1]

Cell Line: A549 human lung epithelial cells
Concentration: 20 μM
Incubation Time: 1 h (pre-incubation before infection); added 1 h post-infection, incubated until 12 hpi
Result: Exhibited strong inhibitory activity when administered before viral adsorption.
Showed substantially diminished potency when added after adsorption.
Matched the inhibitory pattern of a ZIKV envelope protein-neutralizing antibody.
Molecular Weight

391.44

Formula

C19H21NO6S
SMILES

O=C(OCC)C1=C(NC(C2=CC=CO2)=O)SC3=C1CCC(C(OCC)=O)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZIKV-IN-9 Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZIKV-IN-9FlavivirusZika virusVero cellsA549 cellsviral adsorptionZIKV MR766ZIKVZIKV HPF2013envelope proteinZIKV RNA synthesisU251 cellsInhibitorinhibitorinhibit

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