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Cat. No.: HY-18223

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NITD-203

NITD-203 is a RdRp domain inhibitor. NITD 203 induces inhibition of the four DENV serotypes, as well as of YFV and WNV.

For research use only. We do not sell to patients.

CAS No.: 1207518-71-5
Formula: C₂₂H₂₇N₅O₇
Molecular Weight:473.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NITD-203 Chemical Structure

CAS No.: 1207518-71-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

NITD-203 is a RdRp domain inhibitor. NITD 203 induces inhibition of the four DENV serotypes, as well as of YFV and WNV^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	0.54 μM Compound: NITD203	Antiviral activity against Dengue virus 1 MY10245 infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 1 MY10245 infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.54 μM Compound: NITD203	Antiviral activity against Dengue virus 3 MY22366 infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 3 MY22366 infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.57 μM Compound: NITD203	Antiviral activity against Dengue virus 2 MY10340 infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 2 MY10340 infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.69 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 2 NGC infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.71 μM Compound: NITD203	Antiviral activity against Dengue virus 4 MY22713 infected in human A549 cells by CFI assay Antiviral activity against Dengue virus 4 MY22713 infected in human A549 cells by CFI assay	[PMID: 20516277]
A549	EC₅₀	0.76 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 2 mg/ml alpha-1-acid glycoprotein Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 2 mg/ml alpha-1-acid glycoprotein	[PMID: 20516277]
A549	EC₅₀	0.79 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 40 mg/ml human serum albumin Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 40 mg/ml human serum albumin	[PMID: 20516277]
A549	EC₅₀	0.85 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 40 mg/ml human serum albumin and 2 mg/ml alpha-1-acid glycoprotein Antiviral activity against Dengue virus 2 NGC infected in human A549 cells after 2 days by CFI assay in presence of 40 mg/ml human serum albumin and 2 mg/ml alpha-1-acid glycoprotein	[PMID: 20516277]
PBMC	EC₅₀	0.1 μM Compound: NITD203	Antiviral activity against Dengue virus 2 NGC infected in human PBMC cells by plaque assay Antiviral activity against Dengue virus 2 NGC infected in human PBMC cells by plaque assay	[PMID: 20516277]

Chemical Information

CAS No. 1207518-71-5
Molecular Weight 473.48
Formula C₂₂H₂₇N₅O₇
SMILES

O[C@]1(C#C)[C@H](OC(C(C)C)=O)[C@@H](COC(C(C)C)=O)O[C@H]1N2C=C(C(N)=O)C3=C2N=CN=C3N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. García LL, et al. Inhibitors compounds of the flavivirus replication process. Virol J. 2017 May 15;14(1):95. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

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100 mg

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