ToP-DNJ 

ToP-DNJ is a selective endoplasmic reticulum α-glucosidase II (GluII) inhibitor with an IC₅₀ value of 9.0 μM. ToP-DNJ selectively inhibits the two catalytic reactions of GluII, and exhibits stronger activity in the first step of converting di-glycosylated glycans to mono-glycosylated glycans. ToP-DNJ exhibits anti-DENV activity. ToP-DNJ can be used in studies related to dengue virus infection^[1].

ToP-DNJ is a selective inhibitor of isolated endoplasmic reticulum α-glucosidase II, with an IC₅₀ of 9.0 μM, and does not inhibit other tested α- or β-glucosidases at concentrations up to 50 μM^[1].
ToP-DNJ inhibits both catalytic reactions of isolated endoplasmic reticulum α-glucosidase II, with higher inhibitory potency against the first reaction (IC₅₀ = 14 μM) than against the second one (IC₅₀ = 56 μM)^[1].
ToP-DNJ exhibits anti-dengue virus activity in primary human monocyte-derived macrophages with an IC₅₀ of 12.7 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ToP-DNJ (2-10 mg/kg; i.v., p.o.; single dose) preferentially accumulates in the liver of BALB/c mice after both intravenous and oral single-dose administration, with an extended plasma terminal half-life of 8.79 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

661.99

C₄₀H₇₁NO₆

1508303-85-2

O[C@@H]1[C@@H](CO)N(CCCCCOC2=C(C)C(C)=C3C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O3)=C2C)C[C@H](O)[C@H]1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kiappes JL, et al. ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II Exhibiting Antiflaviviral Activity. ACS Chem Biol. 2018;13(1):60-65.  [Content Brief]