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Cat. No.: HY-125426

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ToP-DNJ

ToP-DNJ is a selective endoplasmic reticulum α-glucosidase II (GluII) inhibitor with an IC₅₀ value of 9.0 μM. ToP-DNJ selectively inhibits the two catalytic reactions of GluII, and exhibits stronger activity in the first step of converting di-glycosylated glycans to mono-glycosylated glycans. ToP-DNJ exhibits anti-DENV activity. ToP-DNJ can be used in studies related to dengue virus infection.

For research use only. We do not sell to patients.

CAS No.: 1508303-85-2
Formula: C₄₀H₇₁NO₆
Molecular Weight:661.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ToP-DNJ Chemical Structure

CAS No.: 1508303-85-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

GluII

9.0
μM (IC₅₀)

In Vitro

ToP-DNJ is a selective inhibitor of isolated endoplasmic reticulum α-glucosidase II, with an IC₅₀ of 9.0 μM, and does not inhibit other tested α- or β-glucosidases at concentrations up to 50 μM^[1].
ToP-DNJ inhibits both catalytic reactions of isolated endoplasmic reticulum α-glucosidase II, with higher inhibitory potency against the first reaction (IC₅₀ = 14 μM) than against the second one (IC₅₀ = 56 μM)^[1].
ToP-DNJ exhibits anti-dengue virus activity in primary human monocyte-derived macrophages with an IC₅₀ of 12.7 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2 (Elimination)
Mice^[1]	2 mg/kg	i.v.	/	/	8.79 h
Mice^[1]	10 mg/kg	p.o.	46 nM	8 h	/

In Vivo

ToP-DNJ (2-10 mg/kg; i.v., p.o.; single dose) preferentially accumulates in the liver of BALB/c mice after both intravenous and oral single-dose administration, with an extended plasma terminal half-life of 8.79 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1508303-85-2
Molecular Weight 661.99
Formula C₄₀H₇₁NO₆
SMILES

O[C@@H]1[C@@H](CO)N(CCCCCOC2=C(C)C(C)=C3C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O3)=C2C)C[C@H](O)[C@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kiappes JL, et al. ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II Exhibiting Antiflaviviral Activity. ACS Chem Biol. 2018;13(1):60-65. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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