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Cat. No.: HY-156052

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CN-716 dihydrochloride

CN-716 dihydrochloride is a reversible covalent flavivirus NS2B·NS3 protease inhibitor with antiviral activity. CN-716 dihydrochloride effectively inhibits the replication of dengue virus (DENV2), West Nile virus (WNV) and Zika virus (ZIKV). The IC₅₀ values of CN-716 dihydrochloride against the proteases of the above three viruses are 0.066 μM, 0.11 μM and 0.25 μM, respectively, while the K_i values against the same proteases are 0.051 μM, 0.082 μM and 0.04 μM, respectively. CN-716 dihydrochloride can be used to study the infection mechanisms of dengue fever, West Nile fever and Zika virus infection.

For research use only. We do not sell to patients.

CAS No.: 2077164-48-6
Formula: C₂₂H₃₃BCl₂N₆O₄
Molecular Weight:527.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CN-716 dihydrochloride Chemical Structure

CAS No.: 2077164-48-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

In Vitro

CN-716 dihydrochloride inhibits Dengue virus replication in cell culture with an EC₅₀ of 30 μM^[2].
CN-716 dihydrochloride (up to 100 μM) shows no cytotoxicity in cell culture at concentrations up to 100 μM^[2].
CN-716 dihydrochloride binds to West Nile virus NS2B·NS3 protease in the closed active conformation, forming a covalent bond with Ser135 and multiple specific non-covalent interactions with the protease subsites^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

normal cell
Concentration:

100 μM
Incubation Time:

/
Result:

Showed the CC₅₀>100 μM.

Chemical Information

CAS No. 2077164-48-6
Molecular Weight 527.25
Formula C₂₂H₃₃BCl₂N₆O₄
SMILES

NCC(C=C1)=CC=C1C[C@H](NC(C2=CC=CC=C2)=O)C(N[C@H](B(O)O)CCCNC(N)=N)=O.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mahawaththa M C, et al. Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease[J]. Antiviral research, 2017, 142: 141-147.

[2]. Nitsche C, et al. Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology. J Med Chem. 2017;60(1):511-516. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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