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United States

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製品番号: HY-156052

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CN-716 dihydrochloride

CN-716 dihydrochloride is a reversible covalent flavivirus NS2B·NS3 protease inhibitor with antiviral activity. CN-716 dihydrochloride effectively inhibits the replication of dengue virus (DENV2), West Nile virus (WNV) and Zika virus (ZIKV). The IC₅₀ values of CN-716 dihydrochloride against the proteases of the above three viruses are 0.066 μM, 0.11 μM and 0.25 μM, respectively, while the K_i values against the same proteases are 0.051 μM, 0.082 μM and 0.04 μM, respectively. CN-716 dihydrochloride can be used to study the infection mechanisms of dengue fever, West Nile fever and Zika virus infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2077164-48-6
分子式: C₂₂H₃₃BCl₂N₆O₄
分子量:527.25

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CN-716 dihydrochloride 構造式

CAS 番号: 2077164-48-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

CN-716 dihydrochloride inhibits Dengue virus replication in cell culture with an EC₅₀ of 30 μM^[2].
CN-716 dihydrochloride (up to 100 μM) shows no cytotoxicity in cell culture at concentrations up to 100 μM^[2].
CN-716 dihydrochloride binds to West Nile virus NS2B·NS3 protease in the closed active conformation, forming a covalent bond with Ser135 and multiple specific non-covalent interactions with the protease subsites^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

normal cell
Concentration:

100 μM
Incubation Time:

/
Result:

Showed the CC₅₀>100 μM.

化学情報

CAS 番号 2077164-48-6
分子量 527.25
分子式 C₂₂H₃₃BCl₂N₆O₄
SMILES

NCC(C=C1)=CC=C1C[C@H](NC(C2=CC=CC=C2)=O)C(N[C@H](B(O)O)CCCNC(N)=N)=O.Cl.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Mahawaththa M C, et al. Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease[J]. Antiviral research, 2017, 142: 141-147.

[2]. Nitsche C, et al. Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology. J Med Chem. 2017;60(1):511-516. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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